Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom
dc.contributor.author | Murakami, M. T. | |
dc.contributor.author | Gava, L. M. | |
dc.contributor.author | Zela, S. P. | |
dc.contributor.author | Arruda, E. Z. | |
dc.contributor.author | Melo, P. A. | |
dc.contributor.author | Gutierrez, J. M. | |
dc.contributor.author | Arni, R. K. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Federal do Rio de Janeiro (UFRJ) | |
dc.contributor.institution | Univ Costa Rica | |
dc.date.accessioned | 2014-05-20T15:27:14Z | |
dc.date.available | 2014-05-20T15:27:14Z | |
dc.date.issued | 2004-12-01 | |
dc.description.abstract | Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degreesC. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 Angstrom, Diffraction data was collected to 1.78 Angstrom. (C) 2004 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | Univ Estadual Paulista, Dept Fis, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliation | Univ Fed Rio de Janeiro, Dept Farmacol Basica & Clin, IBC, Rio de Janeiro, RJ, Brazil | |
dc.description.affiliation | Univ Costa Rica, Fac Microbiol, Inst Clodomiro Picado, Escuela Med, San Jose, Costa Rica | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Fis, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | |
dc.format.extent | 83-85 | |
dc.identifier | http://dx.doi.org/10.1016/j.bbapap.2004.08.009 | |
dc.identifier.citation | Biochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1703, n. 1, p. 83-85, 2004. | |
dc.identifier.doi | 10.1016/j.bbapap.2004.08.009 | |
dc.identifier.issn | 1570-9639 | |
dc.identifier.lattes | 9162508978945887 | |
dc.identifier.orcid | 0000-0003-2460-1145 | |
dc.identifier.uri | http://hdl.handle.net/11449/37254 | |
dc.identifier.wos | WOS:000225621800010 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Biochimica et Biophysica Acta: Proteins and Proteomics | |
dc.relation.ispartofjcr | 2.609 | |
dc.relation.ispartofsjr | 1,170 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | suramin | pt |
dc.subject | myotoxicity | pt |
dc.subject | snake venom | pt |
dc.subject | Lys49 PLA(2)s | pt |
dc.subject | X-ray diffraction | pt |
dc.title | Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 9162508978945887[7] | |
unesp.author.orcid | 0000-0003-2460-1145[7] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Física - IBILCE | pt |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: