Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom

dc.contributor.authorMurakami, M. T.
dc.contributor.authorGava, L. M.
dc.contributor.authorZela, S. P.
dc.contributor.authorArruda, E. Z.
dc.contributor.authorMelo, P. A.
dc.contributor.authorGutierrez, J. M.
dc.contributor.authorArni, R. K.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniv Costa Rica
dc.date.accessioned2014-05-20T15:27:14Z
dc.date.available2014-05-20T15:27:14Z
dc.date.issued2004-12-01
dc.description.abstractSuramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degreesC. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 Angstrom, Diffraction data was collected to 1.78 Angstrom. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Fis, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Farmacol Basica & Clin, IBC, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUniv Costa Rica, Fac Microbiol, Inst Clodomiro Picado, Escuela Med, San Jose, Costa Rica
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fis, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent83-85
dc.identifierhttp://dx.doi.org/10.1016/j.bbapap.2004.08.009
dc.identifier.citationBiochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1703, n. 1, p. 83-85, 2004.
dc.identifier.doi10.1016/j.bbapap.2004.08.009
dc.identifier.issn1570-9639
dc.identifier.lattes9162508978945887
dc.identifier.orcid0000-0003-2460-1145
dc.identifier.urihttp://hdl.handle.net/11449/37254
dc.identifier.wosWOS:000225621800010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica et Biophysica Acta: Proteins and Proteomics
dc.relation.ispartofjcr2.609
dc.relation.ispartofsjr1,170
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsuraminpt
dc.subjectmyotoxicitypt
dc.subjectsnake venompt
dc.subjectLys49 PLA(2)spt
dc.subjectX-ray diffractionpt
dc.titleCrystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venomen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes9162508978945887[7]
unesp.author.orcid0000-0003-2460-1145[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentFísica - IBILCEpt

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