Proteomic View of the Venom from the Fire Ant Solenopsis invicta Buren

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dc.contributor.authordos Santos Pinto, Jose R. A. [UNESP]
dc.contributor.authorFox, Eduardo G. P.
dc.contributor.authorSaidemberg, Daniel M. [UNESP]
dc.contributor.authorSantos, Lucilene D. [UNESP]
dc.contributor.authorda Silva Menegasso, Anally R. [UNESP]
dc.contributor.authorCosta-Manso, Eliude
dc.contributor.authorMachado, Ednildo A.
dc.contributor.authorBueno, Odair C. [UNESP]
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionClinica de Alergologia de Pouso Alegre
dc.date.accessioned2014-05-20T13:55:29Z
dc.date.available2014-05-20T13:55:29Z
dc.date.issued2012-09-01
dc.description.abstractFire ants are well-known by their aggressive stinging behavior, causing many stinging incidents of medical importance. The limited availability of fire ant venom for scientific and clinical uses has restricted, up to now, the knowledge about the biochemistry, immunology, and pharmacology of these venoms. For this study, S. invicta venom was obtained commercially and used for proteomic characterization. For this purpose, the combination of gel-based and gel-free proteomic strategies was used to assign the proteomic profile of the venom from the fire ant S. invicta. This experimental approach permitted the identification of 46 proteins, which were organized into four different groups according to their potential role in fire ant venom: true venom components, housekeeping proteins, body muscle proteins, and proteins involved in chemical communication. The active venom components that may not present toxic roles were classified into three subgroups according to their potential functions: self-venom protection, colony asepsis, and chemical communication. Meanwhile, the proteins classified as true toxins, based on their functions after being injected into the victims' bodies by the fire ants, were classified in five other subgroups: proteins influencing the homeostasis of the victims, neurotoxins, proteins that promote venom diffusion, proteins that cause tissue damage/inflammation, and allergens.en
dc.description.affiliationUniv São Paulo State UNESP, Dept Biol, Ctr Study Social Insects, Inst Biosci, Rio Claro, SP, Brazil
dc.description.affiliationFed Univ Rio de Janeiro IBCCF UFRJ, Inst Biofis Carlos Chagas Filho, Lab Entomol Med & Mol, Rio de Janeiro, Brazil
dc.description.affiliationClin Allergol, Pouso Alegre, MG, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Dept Biol, Ctr Study Social Insects, Inst Biosci, Rio Claro, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 05/00982-1
dc.description.sponsorshipIdFAPESP: 06/02115-6
dc.description.sponsorshipIdFAPESP: 11/51684-1
dc.format.extent4643-4653
dc.identifierhttp://dx.doi.org/10.1021/pr300451g
dc.identifier.citationJournal of Proteome Research. Washington: Amer Chemical Soc, v. 11, n. 9, p. 4643-4653, 2012.
dc.identifier.doi10.1021/pr300451g
dc.identifier.issn1535-3893
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19855
dc.identifier.wosWOS:000308389900022
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Proteome Research
dc.relation.ispartofjcr3.950
dc.relation.ispartofsjr1,818
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHymenopteraen
dc.subjectallergenen
dc.subjecttoxinen
dc.subjectproteomic analysisen
dc.subjectmass spectrometryen
dc.subjectshotgun proteomicsen
dc.subjectenvenoming mechanismen
dc.titleProteomic View of the Venom from the Fire Ant Solenopsis invicta Burenen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/copyright/journals/faqs.html
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0001-6141-255X[2]
unesp.author.orcid0000-0001-5832-1825[4]
unesp.author.orcid0000-0002-7363-8211[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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