Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats

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dc.contributor.authorToro, Luan Felipe [UNESP]
dc.contributor.authorde Mello-Neto, João Martins [UNESP]
dc.contributor.authorSantos, Fernanda Furuse Ventura dos [UNESP]
dc.contributor.authorFerreira, Letícia Chaves [UNESP]
dc.contributor.authorStatkievicz, Cristian [UNESP]
dc.contributor.authorCintra, Luciano Tavares Ângelo [UNESP]
dc.contributor.authorIssa, João Paulo Mardegan
dc.contributor.authorDornelles, Rita Cássia Menegati [UNESP]
dc.contributor.authorde Almeida, Juliano Milanezi [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorTheodoro, Leticia Helena [UNESP]
dc.contributor.authorCasatti, Cláudio Aparecido [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T17:00:02Z
dc.date.available2019-10-06T17:00:02Z
dc.date.issued2019-12-01
dc.description.abstractThis study evaluated the effects of local application of autologous platelet-rich plasma (PRP) on the tooth extraction site of rats presenting the main risk factors for medication-related osteonecrosis of the jaw (MRONJ). For seven weeks, senile rats were submitted to systemic treatment with vehicle (VEH and VEH-PRP) or 100 μg/Kg of zoledronate (ZOL and ZOL-PRP) every three days. After three weeks, the first lower molar was extracted. VEH-PRP and ZOL-PRP received PRP at the tooth extraction site. Euthanasia was performed at 28 days postoperatively. Clinical, histopathological, histometric and immunohistochemical analyses were carried out in histological sections from the tooth extraction site. ZOL showed lower percentage of newly formed bone tissue (NFBT), higher percentage of non-vital bone tissue (NVBT), as well as higher immunolabeling for TNFα and IL-1β. In addition, ZOL presented lower immunolabeling for PCNA, VEGF, BMP2/4, OCN and TRAP. VEH and ZOL-PRP showed improvement in the tooth extraction site wound healing and comparable percentage of NFBT, VEGF, BMP2/4 and OCN. Local application of autologous PRP proved a viable preventive therapy, which is safe and effective to restore tissue repair capacity of the tooth extraction site and prevent the occurrence of MRONJ following tooth extraction.en
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Department of Basic Sciences Rua José Bonifácio 1193 CEP
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences Rua Prof. Dr. Antônio Celso Wagner Zanin 250 CEP
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Department of Surgery and Integrated Clinic Rua José Bonifácio 1193 CEP
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Department of Restorative Dentistry Rua José Bonifácio 1193 CEP
dc.description.affiliationSão Paulo University (USP) School of Dentistry Department of Morphology Physiology and Basic Pathology Avenida do Café s/n CEP
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Department of Basic Sciences Rua José Bonifácio 1193 CEP
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences Rua Prof. Dr. Antônio Celso Wagner Zanin 250 CEP
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Department of Surgery and Integrated Clinic Rua José Bonifácio 1193 CEP
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Department of Restorative Dentistry Rua José Bonifácio 1193 CEP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/26779-4
dc.identifierhttp://dx.doi.org/10.1038/s41598-018-37063-y
dc.identifier.citationScientific Reports, v. 9, n. 1, 2019.
dc.identifier.doi10.1038/s41598-018-37063-y
dc.identifier.issn2045-2322
dc.identifier.lattes4408095517346846
dc.identifier.lattes8399870097572073
dc.identifier.lattes5435902422784889
dc.identifier.lattes8487462626931877
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.orcid0000-0003-0783-6612
dc.identifier.orcid0000-0001-5650-7343
dc.identifier.scopus2-s2.0-85059829195
dc.identifier.urihttp://hdl.handle.net/11449/190032
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleApplication of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[14]
unesp.author.lattes8399870097572073
unesp.author.lattes5435902422784889[8]
unesp.author.lattes8487462626931877[13]
unesp.author.orcid0000-0002-1049-4257[1]
unesp.author.orcid0000-0003-4859-0583[14]
unesp.author.orcid0000-0003-0783-6612[8]
unesp.author.orcid0000-0001-5650-7343[13]

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Artigos - Odontologia Restauradora - FOA
Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Ciências Básicas - FOA