Advanced Glycation End Products Inhibitors from Talisia esculenta

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dc.contributor.authorAlves, Natalia Felix [UNESP]
dc.contributor.authorRibeiro, Dayane Castro [UNESP]
dc.contributor.authorMannochio-Russo, Helena [UNESP]
dc.contributor.authorQueiroz, Suzana Aparecida Silva [UNESP]
dc.contributor.authorZocolo, Guilherme Juliao
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorValli, Marilia
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T12:00:27Z
dc.date.available2023-07-29T12:00:27Z
dc.date.issued2023-04-24
dc.description.abstractAdvanced Glycation End Products (AGEs) are formed under hyperglycemic conditions but also during the natural aging process. AGEs are associated with skin aging, loss of skin elasticity, and some chronic diseases such as diabetes and Alzheimer ' s, being a research topic of great relevance. Several herbal supplements have beneficial effects on glycemic control and oxidative stress, with the consequent reduction in the volume of AGEs during aging. In this scenario, the search for natural products with AGEs inhibition activity has been gaining prominence due to their importance for innovation in pharmaceuticals and cosmetics. The present study describes the investigation of natural products from Talisia esculenta with antiglycation activity. Ten phenolic compounds were annotated by LC-MS, and the compounds present in the leaves extracts were isolated, characterized by NMR and submitted for further in vitro studies. Rutin and quercitrin were isolated and presented 44% and 86% antiglycation activity at 150 mu g/mL. These results open new possibilities for the use of abundant natural compounds as AGEs inhibitors, and further studies should be performed to evaluate their use and efficacy in cosmetics formulations and even in the treatment of AGEs-associated diseases.en
dc.description.affiliationUniv Estadual Paulista, Inst Chem Nucleus Bioassays, Dept Organ Chem, Biosynth & Ecophysiol Nat Prod NuBBE, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationEmbrapa Agroind Trop, Rua Dra Sara Mesquita 2270,Bairro Planalto P, BR-60511110 Fortaleza, CE, Brazil
dc.description.affiliationUniv Sao Paulo, Sao Carlos Inst Phys, Ctr Res & Innovat Biodivers & Drug Discovery, Lab Med & Computat Chem LQMC, Ave Joao Dagnone 1100, BR-13563120 Sao Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Chem Nucleus Bioassays, Dept Organ Chem, Biosynth & Ecophysiol Nat Prod NuBBE, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo de Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoa de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2013/07600-3
dc.description.sponsorshipIdFAPESP: 2014/50926-0
dc.description.sponsorshipIdFAPESP: 2020/11967-3
dc.description.sponsorshipIdFAPESP: 2019/05967-3
dc.description.sponsorshipIdCNPq: 142014/2018-4
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.21577/1984-6835.20230019
dc.identifier.citationRevista Virtual de Quimica. Sao Paulo: Soc Brasileira Quimica, 7 p., 2023.
dc.identifier.doi10.21577/1984-6835.20230019
dc.identifier.issn1984-6835
dc.identifier.urihttp://hdl.handle.net/11449/245626
dc.identifier.wosWOS:000981499800001
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofRevista Virtual De Quimica
dc.sourceWeb of Science
dc.subjectAdvanced glycation
dc.subjectnatural products
dc.subjectTalisia esculenta
dc.subjectSapindaceae
dc.subjectbioeconomy
dc.titleAdvanced Glycation End Products Inhibitors from Talisia esculentaen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica

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Artigos - Química Orgânica - IQ