Luminescent mesoporous silica nanohybrid based on drug derivative terbium complex

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dc.contributor.authorMaturi, Fernando E. [UNESP]
dc.contributor.authorSábio, Rafael M.
dc.contributor.authorSilva, Robson R.
dc.contributor.authorLahoud, Marcelo G. [UNESP]
dc.contributor.authorMeneguin, Andréia B.
dc.contributor.authorValente, Gustavo T.
dc.contributor.authorCaface, Raphael A.
dc.contributor.authorLeite, Ilaiáli S.
dc.contributor.authorInada, Natalia M.
dc.contributor.authorRibeiro, Sidney J. L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T17:06:31Z
dc.date.available2019-10-06T17:06:31Z
dc.date.issued2019-03-01
dc.description.abstractMesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine.en
dc.description.affiliationInstitute of Chemistry São Paulo State University-UNESP
dc.description.affiliationSão Carlos Institute of Physics University of São Paulo-USP
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University-UNESP
dc.identifierhttp://dx.doi.org/10.3390/ma12060933
dc.identifier.citationMaterials, v. 16, n. 6, 2019.
dc.identifier.doi10.3390/ma12060933
dc.identifier.issn1996-1944
dc.identifier.scopus2-s2.0-85063543684
dc.identifier.urihttp://hdl.handle.net/11449/190232
dc.language.isoeng
dc.relation.ispartofMaterials
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectKetoprofen
dc.subjectLuminescent nanohybrid
dc.subjectMesoporous silica nanoparticles
dc.subjectTerbium
dc.subjectTwo-photon
dc.titleLuminescent mesoporous silica nanohybrid based on drug derivative terbium complexen
dc.typeArtigo

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