Involvement of opioid system, TRPM8, and ASIC receptors in antinociceptive effect of Arrabidaea brachypoda (DC) bureau

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dc.contributor.authorRodrigues, Vinícius Peixoto [UNESP]
dc.contributor.authorDa Rocha, Cláudia Quintino
dc.contributor.authorPérico, Larissa Lucena [UNESP]
dc.contributor.authorDe Cássia dos Santos, Raquel
dc.contributor.authorOhara, Rie [UNESP]
dc.contributor.authorNishijima, Catarine Massucato [UNESP]
dc.contributor.authorQueiroz, Emerson Ferreira
dc.contributor.authorWolfender, Jean-Luc
dc.contributor.authorDa Rocha, Lúcia Regina Machado [UNESP]
dc.contributor.authorSantos, Adair Roberto Soares
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Maranhão
dc.contributor.institutionClinical Pharmacology and Gastroenterology Unit (USF)
dc.contributor.institutionUniversity of Lausanne
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.date.accessioned2018-12-11T17:34:47Z
dc.date.available2018-12-11T17:34:47Z
dc.date.issued2017-11-02
dc.description.abstractArrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as “ció-una”, it is popularly used as a natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition and antinociceptive activity of the dichloromethane fraction from the roots of A. brachypoda (DEAB) and its mechanism of action. The chemical composition was characterized by high-performance liquid chromatography, and this fraction is composed only of dimeric flavonoids. The antinociceptive effect was evaluated in formalin and hot plate tests after oral administration (10-100 mg/kg) in male Swiss mice. We also investigated the involvement of TRPV1 (transient receptor potential vanilloid 1), TRPA1 (transient receptor potential ankyrin 1), TRPM8 (transient receptor potential melastatin 8), and ASIC (acid-sensing ion channel), as well as the opioidergic, glutamatergic, and supraspinal pathways. Moreover, the nociceptive response was reduced (30 mg/kg) in the early and late phase of the formalin test. DEAB activity appears to involve the opioid system, TRPM8, and ASIC receptors, clearly showing that the DEAB alleviates acute pain in mice and suggesting the involvement of the TRPM8 and ASIC receptors and the opioid system in acute pain relief.en
dc.description.affiliationSão Paulo State University (UNESP) Biosciences Institute Department of Physiology
dc.description.affiliationDepartment of Chemistry Federal University of Maranhão, Av. dos Portugueses, 1966â-Bacanga
dc.description.affiliationClinical Pharmacology and Gastroenterology Unit (USF)
dc.description.affiliationSchool of Pharmaceutical Sciences EPGL University of Geneva University of Lausanne, CMU-Rue Michel-Servet 1
dc.description.affiliationFederal University of Santa Catarina Laboratory of Neurobiology of Pain and Inflammation Department of Physiological Sciences Center of Biological Sciences, Trindade
dc.description.affiliationBiosciences Institute São Paulo State University (UNESP)
dc.description.affiliationUnespSão Paulo State University (UNESP) Biosciences Institute Department of Physiology
dc.description.affiliationUnespBiosciences Institute São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2009/52237-9
dc.description.sponsorshipIdCNPq: 305570/2012-9
dc.identifierhttp://dx.doi.org/10.3390/ijms18112304
dc.identifier.citationInternational Journal of Molecular Sciences, v. 18, n. 11, 2017.
dc.identifier.doi10.3390/ijms18112304
dc.identifier.file2-s2.0-85033554118.pdf
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.scopus2-s2.0-85033554118
dc.identifier.urihttp://hdl.handle.net/11449/179343
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.ispartofsjr1,260
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntinociceptive effect
dc.subjectArrabidaea brachypoda (dc) bureau
dc.subjectBignoniaceae
dc.subjectPain
dc.titleInvolvement of opioid system, TRPM8, and ASIC receptors in antinociceptive effect of Arrabidaea brachypoda (DC) bureauen
dc.typeArtigo
unesp.author.lattes3814504901386844[12]
unesp.author.orcid0000-0002-8645-3777[12]

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