Severe distal cytomegalovirus esophagitis with aerodigestive symptoms in an immunocompetent infant

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dc.contributor.authorMachado, Nilton Carlos [UNESP]
dc.contributor.authorCarvalho, Mary de Assis [UNESP]
dc.contributor.authorOrtolan, Erika Veruska Paiva[UNESP]
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-04-01T18:43:39Z
dc.date.available2016-04-01T18:43:39Z
dc.date.issued2013
dc.description.abstractWe report a case of an immunocompetent infant, with no evidence of neurological disorders, which developed clinical manifestation of recurrent crisis of choking, dysphagia, laryngeal stridor and sub costal retractions since the first day of life. Direct laryngoscopy was unremarkable. Upper gastrointestinal series showed a dilated tortuous esophagus with severe peristalsis impairment and reflux episodes till the proximal third of the esophagus. An upper gastrointestinal endoscopy showed a moderately dilated esophagus with erosive lesions in the distal esophagus. Esophageal biopsy specimens revealed CMV inclusion bodies associated to moderate inflammation and immunohistochemistry was positive for CMV early antigen. Prolonged 24 h esophageal pH metry was within normal limits. Antiviral therapy with intravenous ganciclovir was introduced and was associated with rapid improvement of the symptoms. Child gradually increased oral intake and weight gain, and there were no side effects related to therapy. Thus, the respiratory symptoms could have been a supra esophageal manifestation of a non-acid reflux disease related to the CMV esophagitis.en
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Pediatria, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de Botucatu
dc.format.extent40-43
dc.identifierhttp://dx.doi.org/10.4021/ijcp78w
dc.identifier.citationInternational Journal of Clinical Pediatrics, v. 2, n. 1, p. 40-43, 2013.
dc.identifier.doi10.4021/ijcp78w
dc.identifier.fileISSN1927-1255-2013-02-01-40-43.pdf
dc.identifier.issn1927-1255
dc.identifier.lattes4729603720628835
dc.identifier.lattes1576374151262910
dc.identifier.lattes4428524305554124
dc.identifier.orcid0000-0002-9697-3450
dc.identifier.urihttp://hdl.handle.net/11449/136985
dc.language.isoeng
dc.relation.ispartofInternational Journal of Clinical Pediatrics
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectCytomegalovirusen
dc.subjectEsophagitisen
dc.subjectGancicloviren
dc.subjectImmunocompetent infanten
dc.subjectImmunohistochemistryen
dc.titleSevere distal cytomegalovirus esophagitis with aerodigestive symptoms in an immunocompetent infanten
dc.typeArtigo
unesp.author.lattes4729603720628835
unesp.author.lattes1576374151262910
unesp.author.lattes4428524305554124(3)
unesp.author.orcid0000-0002-9697-3450(3)
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentPediatriapt
unesp.departmentCirurgia e Ortopedia - FMBpt
unesp.departmentPatologiapt

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