Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes

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dc.contributor.authorTeresa, Debora Barreto [UNESP]
dc.contributor.authorSantos, Raquel Alves
dc.contributor.authorTakahashi, Catarina Satie
dc.contributor.authorCarrara, Helio H.
dc.contributor.authorMoreira, Haroldo Wilson [UNESP]
dc.contributor.authorMattos, Luis Carlos
dc.contributor.authorLia-Neto, Nicolino
dc.contributor.authorCunha, Leonardo A.
dc.contributor.authorBassi, Carmem Lucia
dc.contributor.authorSoares, Edson Garcia
dc.contributor.authorDonadi, Eduardo Antonio
dc.contributor.authorMello, Elaine Rodrigues [UNESP]
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionInst Surg Pathol & Cytopathol IPC
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.date.accessioned2014-05-20T13:24:01Z
dc.date.available2014-05-20T13:24:01Z
dc.date.issued2010-10-01
dc.description.abstractABH and Lewis antigen expression has been associated with cancer development and prognosis, tumor differentiation, and metastasis. Considering that invasive ductal breast carcinoma (IDC) presents multiple molecular alterations, the aim of the present study was to determine whether the polymorphism of ABO, Lewis, and Secretor genes, as well as ABO phenotyping, could be associated with tumor differentiation and lymph nodes metastasis. Seventy-six women with IDC and 78 healthy female blood donors were submitted to ABO phenotyping/genotyping and Lewis and Secretor genotyping. Phenotyping was performed by hemagglutination and genotyping by the polymerase chain reaction with sequence-specific primers. ABO, Lewis, and Secretor genes were classified by individual single nucleotide polymorphism at sites 59, 1067, 202, and 314 of the Lewis gene, 428 of the Secretor gene, and 261 (O1 allele), 526 (O2 and B allele), and 703 (B allele). No association was found between breast cancer and ABO antigen expression (P = 0.9323) or genotype (P = 0.9356). Lewis-negative genotype was associated with IDC (P = 0.0126) but not with anatomoclinical parameters. Nonsecretor genotype was associated with axillary lymph node metastasis (P = 0.0149). In conclusion, Lewis and Secretor genotyping could be useful to predict respectively breast cancer susceptibility and axillary lymph nodes metastasis.en
dc.description.affiliationUniv São Paulo State, Sch Pharmaceut Sci, UNESP, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, BR-14041900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUSP, Fac Philosophy Sci & Letters Ribeirao Preto, BR-14041900 Ribeirao Preto, SP, Brazil
dc.description.affiliationFac Med Sao Jose Rio Preto FAMERP, BR-15090000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationInst Surg Pathol & Cytopathol IPC, BR-14801320 Araraquara, SP, Brazil
dc.description.affiliationFed Univ MG UFMT, Ctr Oncol Araraquara City CORA, BR-78060900 Cuiaba, MG, Brazil
dc.description.affiliationFed Univ MG UFMT, Fac Med Sci, BR-78060900 Cuiaba, MG, Brazil
dc.description.affiliationUniversidade Federal do Espírito Santo (UFES) UFES, Ctr Univ Norte Espirito Santo, BR-29932540 Sao Mateus, ES, Brazil
dc.description.affiliationUnespUniv São Paulo State, Sch Pharmaceut Sci, UNESP, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipFUNDU NESP
dc.description.sponsorshipFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA)
dc.format.extent401-409
dc.identifierhttp://dx.doi.org/10.1007/s13277-010-0048-2
dc.identifier.citationTumor Biology. Dordrecht: Springer, v. 31, n. 5, p. 401-409, 2010.
dc.identifier.doi10.1007/s13277-010-0048-2
dc.identifier.issn1010-4283
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/7365
dc.identifier.wosWOS:000282423500004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofTumor Biology
dc.relation.ispartofsjr1,149
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectABOen
dc.subjectLewisen
dc.subjectSecretoren
dc.subjectGenotypingen
dc.subjectPhenotypingen
dc.subjectHuman breast canceren
dc.titlePolymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodesen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1768025290373669[13]
unesp.author.orcid0000-0003-1740-7360[13]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas