Advances in prodrug design
dc.contributor.author | Távora de Albuquerque Silva, Antonio [UNESP] | |
dc.contributor.author | Chin, Chung Man [UNESP] | |
dc.contributor.author | Castro, Lúcia Fioravanti [UNESP] | |
dc.contributor.author | Carvalho Güido, Rafael Victorio [UNESP] | |
dc.contributor.author | Ferreira, Elizabeth Igne | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2014-05-27T11:21:38Z | |
dc.date.available | 2014-05-27T11:21:38Z | |
dc.date.issued | 2005-10-01 | |
dc.description.abstract | The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd. | en |
dc.description.affiliation | Laboratório de Pesquisa e Desenvolvimento de Fármacos Departamento de Fármacos e Medicamentos UNESP, Araraquara | |
dc.description.affiliation | Laboratório de Planejamento e Síntese de Quimioterápicos Potencialmente Ativos Departamento de Farmácia USP/SP, São Paolo | |
dc.description.affiliationUnesp | Laboratório de Pesquisa e Desenvolvimento de Fármacos Departamento de Fármacos e Medicamentos UNESP, Araraquara | |
dc.format.extent | 893-914 | |
dc.identifier | http://dx.doi.org/10.2174/138955705774329528 | |
dc.identifier.citation | Mini-Reviews in Medicinal Chemistry, v. 5, n. 10, p. 893-914, 2005. | |
dc.identifier.doi | 10.2174/138955705774329528 | |
dc.identifier.issn | 1389-5575 | |
dc.identifier.lattes | 9734333607975413 | |
dc.identifier.orcid | 0000-0003-4141-0455 | |
dc.identifier.scopus | 2-s2.0-24944549193 | |
dc.identifier.uri | http://hdl.handle.net/11449/68433 | |
dc.identifier.wos | WOS:000231837000003 | |
dc.language.iso | eng | |
dc.relation.ispartof | Mini-Reviews in Medicinal Chemistry | |
dc.relation.ispartofjcr | 2.645 | |
dc.relation.ispartofsjr | 0,567 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Scopus | |
dc.subject | Latent advanced systems | |
dc.subject | Macromolecules carriers | |
dc.subject | Prodrug design | |
dc.subject | Selective delivery systems | |
dc.subject | aminosalicylic acid | |
dc.subject | ampicillin | |
dc.subject | antiinflammatory agent | |
dc.subject | antileishmanial agent | |
dc.subject | antimalarial agent | |
dc.subject | antineoplastic agent | |
dc.subject | bisphosphonic acid derivative | |
dc.subject | cytochrome P450 | |
dc.subject | diclofenac | |
dc.subject | doxorubicin | |
dc.subject | flucytosine | |
dc.subject | ibuprofen | |
dc.subject | irinotecan | |
dc.subject | isoniazid | |
dc.subject | ketoprofen | |
dc.subject | mevinolin | |
dc.subject | mitomycin | |
dc.subject | nitrofural | |
dc.subject | paclitaxel derivative | |
dc.subject | photosensitizing agent | |
dc.subject | prodrug | |
dc.subject | salazosulfapyridine | |
dc.subject | tacrolimus | |
dc.subject | testosterone derivative | |
dc.subject | tiaprofenic acid | |
dc.subject | tolmetin | |
dc.subject | trigonelline | |
dc.subject | tryptamine derivative | |
dc.subject | unindexed drug | |
dc.subject | antibody directed enzyme prodrug therapy | |
dc.subject | bactericidal activity | |
dc.subject | binding affinity | |
dc.subject | blood brain barrier | |
dc.subject | Chagas disease | |
dc.subject | diarrhea | |
dc.subject | drug absorption | |
dc.subject | drug activation | |
dc.subject | drug design | |
dc.subject | drug distribution | |
dc.subject | drug identification | |
dc.subject | drug receptor binding | |
dc.subject | drug screening | |
dc.subject | drug selectivity | |
dc.subject | drug stability | |
dc.subject | drug structure | |
dc.subject | drug synthesis | |
dc.subject | drug targeting | |
dc.subject | drug transformation | |
dc.subject | gastrointestinal toxicity | |
dc.subject | gene expression | |
dc.subject | human | |
dc.subject | hypercholesterolemia | |
dc.subject | in vivo study | |
dc.subject | macromolecule | |
dc.subject | malaria | |
dc.subject | minimum inhibitory concentration | |
dc.subject | nephrotoxicity | |
dc.subject | organoleptic property | |
dc.subject | osteoporosis | |
dc.subject | review | |
dc.subject | rheumatoid arthritis | |
dc.subject | structure activity relation | |
dc.subject | structure analysis | |
dc.subject | tuberculosis | |
dc.subject | ulcerative colitis | |
dc.subject | Animals | |
dc.subject | Antibodies | |
dc.subject | Drug Carriers | |
dc.subject | Drug Delivery Systems | |
dc.subject | Drug Design | |
dc.subject | Gene Therapy | |
dc.subject | Humans | |
dc.subject | Lectins | |
dc.subject | Macromolecular Substances | |
dc.subject | Osteoporosis | |
dc.subject | Prodrugs | |
dc.subject | Viruses | |
dc.title | Advances in prodrug design | en |
dc.type | Resenha | |
dcterms.license | http://www.benthamscience.com/permission.php | |
unesp.author.lattes | 9734333607975413[2] | |
unesp.author.orcid | 0000-0002-7187-0818[4] | |
unesp.author.orcid | 0000-0003-4141-0455[2] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |