Peritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparin

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dc.contributor.authorAlonso, Juliana de Moura [UNESP]
dc.contributor.authorTakahira, Regina Kiomi [UNESP]
dc.contributor.authorBachiega, Tatiana Fernanda [UNESP]
dc.contributor.authorRodrigues, Karoline Alves [UNESP]
dc.contributor.authorYamada, Ana Lúcia Miluzzi [UNESP]
dc.contributor.authorAlves, Ana Liz Garcia [UNESP]
dc.contributor.authorWatanabe, Marcos Jun [UNESP]
dc.contributor.authorRodrigues, Celso Antônio [UNESP]
dc.contributor.authorHussni, Carlos Alberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-07-07T12:34:23Z
dc.date.available2016-07-07T12:34:23Z
dc.date.issued2014
dc.description.abstractStudy rationale: Heparin is routinely administered postoperatively in abdominal surgery to prevent the formation of adhesions; however, there is no consensus in the literature indicating the effectiveness of such use. Objectives: This study sought to assess peritoneal fibrinolytic activity post-enterotomy of the small colon in equines treated with heparin. Methods: In the present study, 10 adult equines were divided into 2 groups of 5 animals each: the control group (CG) and treated group (TG). Both groups underwent laparotomy and enterotomy of the small colon through the right paralumbar fossa in quadrupedal position. In addition, the animals received combinations of flunixin meglumine, gentamicin and penicillin. The TG also received subcutaneous heparin (150 IU/kg, bwt q. 12 hours, 5 days). The animals were evaluated for the peritoneal concentrations of tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and D-dimer at the following time-points: prior to enterotomy (M0); 12 hours after (M1); 1 day after (M2); 2 days after (M3); 4 days after (M4); 6 days after (M5); 10 days after (M6) and 14 days after enterotomy (M7). Results: A significant difference in tPA level was observed between the groups when all time-points were combined, with a median value of 2.59 IU/mL for the CG and 2.03 IU/mL for the TG. Although no significant difference was observed when the groups were compared at different time-points, smaller tPA and D-dimer values were observed for the TG during heparin treatment. Conclusions: In addition to the finding that the TG showed a lower tPA concentration and reduced D-dimer formation, it was concluded that heparin treatment decreased the formation of fibrin clots and peritoneal fibrinolytic activity.Relevance: Because elevated D-dimer levels are directly related to a poor prognosis and high mortality rate, this study reinforced the relevance of the use of heparin in hypercoagulable states and following abdominal surgery.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Clínica Veterinária, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2011/23359-9
dc.format.extent6-13
dc.identifierhttp://www.sjournals.com/index.php/SJVA/article/view/1070
dc.identifier.citationScientific Journal of Veterinary Advances, v. 3, n. 1, p. 6-13, 2014.
dc.identifier.fileISSN2322-1879-2014-03-01-06-13.pdf
dc.identifier.issn2322-1879
dc.identifier.lattes4663463575469428
dc.identifier.lattes3517825410178813
dc.identifier.lattes7773733250141398
dc.identifier.lattes6020984937849801
dc.identifier.lattes7989397951395253
dc.identifier.orcid0000-0003-3323-4199
dc.identifier.urihttp://hdl.handle.net/11449/140552
dc.language.isoeng
dc.relation.ispartofScientific Journal of Veterinary Advances
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectTissue plasminogen activatoren
dc.subjectHorseen
dc.subjectD-dimeren
dc.subjectFibrinolysisen
dc.subjectHeparin plasminogen activator inhibitoren
dc.titlePeritoneal fibrinolytic activity in equines subjected to small colon enterotomy and treated with heparinen
dc.typeArtigo
unesp.author.lattes4663463575469428
unesp.author.lattes3517825410178813
unesp.author.lattes7773733250141398[6]
unesp.author.lattes6020984937849801[9]
unesp.author.lattes7989397951395253
unesp.author.orcid0000-0003-3323-4199[2]
unesp.author.orcid0000-0001-9092-7819[6]
unesp.author.orcid0000-0001-5421-2904[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentClínica Veterináriapt
unesp.departmentCirurgia e Anestesiologia Veterináriapt

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