Antiglycation and antitumoral activity of Tribulus terrestris dry extract

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dc.contributor.authorFigueiredo, Célia Cristina Malaguti [UNESP]
dc.contributor.authorGomes, Amanda Costa [UNESP]
dc.contributor.authorGranero, Filipe Oliveira [UNESP]
dc.contributor.authorJunior, João Luiz Bronzel [UNESP]
dc.contributor.authorSilva, Luciana Pereira
dc.contributor.authorRuiz, Ana Lúcia Tasca Gois
dc.contributor.authorda Silva, Regildo Márcio Gonçalves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFundação Educacional do Município de Assis (FEMA)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2022-04-28T19:46:41Z
dc.date.available2022-04-28T19:46:41Z
dc.date.issued2021-05-01
dc.description.abstractObjective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type.en
dc.description.affiliationSão Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationFundação Educacional do Município de Assis (FEMA)
dc.description.affiliationUniversity of Campinas (UNICAMP) Faculty of Pharmaceutical Sciences
dc.description.affiliationSão Paulo State University (UNESP) School of Sciences Humanities and Languages Department of Biotechnology Laboratory of Herbal Medicine and Natural Products
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Sciences Humanities and Languages Department of Biotechnology Laboratory of Herbal Medicine and Natural Products
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/17893-3
dc.format.extent224-237
dc.identifierhttp://dx.doi.org/10.22038/AJP.2020.16957
dc.identifier.citationAvicenna Journal of Phytomedicine, v. 11, n. 3, p. 224-237, 2021.
dc.identifier.doi10.22038/AJP.2020.16957
dc.identifier.issn2228-7949
dc.identifier.issn2228-7930
dc.identifier.scopus2-s2.0-85118420372
dc.identifier.urihttp://hdl.handle.net/11449/222791
dc.language.isoeng
dc.relation.ispartofAvicenna Journal of Phytomedicine
dc.sourceScopus
dc.subjectAntiproliferative
dc.subjectProtein glycation
dc.subjectSteroidal saponins
dc.subjectTribulus terrestris
dc.titleAntiglycation and antitumoral activity of Tribulus terrestris dry extracten
dc.typeArtigo

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