Early impairment of cognitive functions in Parkinson's disease

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Stella, Florindo [UNESP]
Gobbi, Lilian T. B. [UNESP]
Gobbi, Sebastião [UNESP]
Oliani, Merlyn M. [UNESP]
Tanaka, Kátia [UNESP]
Pieruccini-Faria, Frederico [UNESP]

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Background: Impairment in non-motor functions such as disturbances of some executive functions are also common events in Parkinson's disease patients. Objective: To verify the performance of Parkinson's disease patients in activities requiring visuoconstructive and visuospatial skills. Method: Thirty elderly patients with mild or moderate stages of Parkinson's disease were studied. The assessment of the clinical condition was based on the unified Parkinson's disease rating scale (56.28; SD=33.48), Hoehn and Yahr (2.2; SD=0.83), Schwab and England (78.93%), clock drawing test (7.36; SD=2.51), and mini-mental state examination (26.48; SD=10.11). Pearson's correlation and stepwise multiple regression were used for statistical analyses. Results: The patients presented deterioration in visuospatial and visuoconstructive skills. Conclusion: The clock drawing test proved to be a useful predictive tool for identifying early cognitive impairment in these individuals.



Cognition disorders, Neuropsychological tests, Parkinson's disease, pramipexole, selegiline, clinical assessment tool, cognitive defect, correlation coefficient, depth perception, early diagnosis, monotherapy, motor performance, neuropsychological test, outcome assessment, Parkinson disease, predictor variable, statistical analysis, Unified Parkinson Disease Rating Scale, Severity of Illness Index, Space Perception, Visual Perception

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Arquivos de Neuro-Psiquiatria, v. 65, n. 2 B, p. 406-410, 2007.