Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio

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dc.contributor.authorBustos-Obregón, Eduardo
dc.contributor.authorPoblete, Daniel
dc.contributor.authorCatriao, Roberto
dc.contributor.authordel Sol, Mariano
dc.contributor.authorFernandes, Fábio Henrique [UNESP]
dc.contributor.institutionUniversidad de La Frontera
dc.contributor.institutionMedical School
dc.contributor.institutionUniversidad Santo Tomás
dc.contributor.institutionUniversidad Autónoma de Chile
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T18:59:27Z
dc.date.available2022-04-28T18:59:27Z
dc.date.issued2013-12-01
dc.description.abstractWe evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days.en
dc.description.affiliationUniversidad de La Frontera, Temuco
dc.description.affiliationUniversity of Chile Medical School, Santiago
dc.description.affiliationVeterinary School Universidad Santo Tomás
dc.description.affiliationCentro de Investigación en Ciencias Biomédicas Universidad Autónoma de Chile, Temuco
dc.description.affiliationSão Paulo State University, Botucatu
dc.description.affiliationUnespSão Paulo State University, Botucatu
dc.format.extent1251-1256
dc.identifierhttp://dx.doi.org/10.4067/S0717-95022013000400017
dc.identifier.citationInternational Journal of Morphology, v. 31, n. 4, p. 1251-1256, 2013.
dc.identifier.doi10.4067/S0717-95022013000400017
dc.identifier.issn0717-9367
dc.identifier.issn0717-9502
dc.identifier.scopus2-s2.0-84894276180
dc.identifier.urihttp://hdl.handle.net/11449/220083
dc.language.isoeng
dc.language.isospa
dc.relation.isnodouble229524*
dc.relation.ispartofInternational Journal of Morphology
dc.sourceScopus
dc.subjectArsenic
dc.subjectDNA stability
dc.subjectMelatonin
dc.subjectMouse
dc.subjectSperm
dc.titleRol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodioes
dc.title.alternativeMelatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arseniteen
dc.typeArtigo

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