Admission hypothermia, neonatal morbidity, and mortality: evaluation of a multicenter cohort of very low birth weight preterm infants according to relative performance of the center

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dc.contributor.authorSiqueira Caldas, Jamil Pedro de
dc.contributor.authorFerri, Walusa A. G.
dc.contributor.authorMarba, Sergio T. M.
dc.contributor.authorAragon, Davi C.
dc.contributor.authorGuinsburg, Ruth
dc.contributor.authorAlmeida, Maria F. B. de
dc.contributor.authorDiniz, Edna M. A.
dc.contributor.authorSilveira, Rita C. S.
dc.contributor.authorAlves Junior, Jose M. S.
dc.contributor.authorPavanelli, Marco B.
dc.contributor.authorBentlin, Maria R. [UNESP]
dc.contributor.authorFerreira, Daniela M. L. M.
dc.contributor.authorVale, Marynea S.
dc.contributor.authorFiori, Humberto H.
dc.contributor.authorDuarte, Jose L. M. B.
dc.contributor.authorMeneses, Jucille A.
dc.contributor.authorCwajg, Silvia
dc.contributor.authorCarvalho, Werther B.
dc.contributor.authorFerrari, Ligia S. L.
dc.contributor.authorSilva, Nathalia M. M.
dc.contributor.authorSilva, Regina P. G. V. C. da
dc.contributor.authorAnchieta, Leni M.
dc.contributor.authorSantos, Juliana P. F.
dc.contributor.authorKawakami, Mandira D.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Crianca
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionMaternidade Hilda Brandao
dc.contributor.institutionHosp Geral Pirajussara
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniv Fed Maranhao
dc.contributor.institutionPontificia Univ Catolica Rio Grande do Sul
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionInst Med Integral Prof Fernando Figueira
dc.contributor.institutionFundacao Oswaldo Cruz
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionHosp Estadual Diadema
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionHosp Estadual Sumare
dc.date.accessioned2019-10-04T12:14:16Z
dc.date.available2019-10-04T12:14:16Z
dc.date.issued2019-07-01
dc.description.abstractThis prospective cohort study aimed to assess the association of admission hypothermia (AH) with death and/or major neonatal morbidities among very low birth weight (VLBW) preterm infants based on the relative performance of 20 centers of the Brazilian Network of Neonatal Research. This is a retrospective analysis of prospectively collected data using the database registry of the Brazilian Network on Neonatal Research. Center performance was defined by the relative mortality rate using conditional inference trees. A total of 4356 inborn singleton VLBW preterm infants born between January 2013 and December 2016 without malformations were included in this study. The centers were divided into two groups: G1 (with lower mortality rate) and G2 (with higher mortality rate). Crude and adjusted relative risks (RR) and 95% confidence intervals (95%CI) were estimated by simple and multiple log-binomial regression models. An AH rate of 53.7% (19.8-93.3%) was significantly associated with early neonatal death in G1 (adjusted RR 1.41, 95% CI 1.09-1.84) and G2 (adjusted RR 1.29, 95%CI 1.01-1.65) and with in-hospital death in G1 (adjusted RR 1.29, 95%CI 1.07-1.58). AH was significantly associated with a lower frequency of necrotizing enterocolitis (adjusted RR 0.58, 95%CI 38-0.88) in G2.Conclusion: AH significantly associated with early neonatal death regardless of the hospital performance. In G2, an unexpected protective association between AH and necrotizing enterocolitis was found, whereas the other morbidities assessed were not significantly associated with AH.en
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Med, Dept Pediat, Campinas, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Ave Bandeirantes 3900, BR-14049900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Neonatal Med, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Pediat, Sch Med, Sao Paulo, Brazil
dc.description.affiliationInst Crianca, Ave Dr Eneas de Carvalho Aguiar,647 Pinheiros, BR-05403000 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, HCPA, Div Neonatol, Rua Silva Jardim 1155-701, BR-90450071 Porto Alegre, RS, Brazil
dc.description.affiliationMaternidade Hilda Brandao, Fac Ciencias Med Minas Gerais, Dept Pediat, Belo Horizonte, MG, Brazil
dc.description.affiliationHosp Geral Pirajussara, Neonatal Unit, Taboao Da Serra, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Div Neonatol, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Uberlandia, Dept Pediat, Uberlandia, MG, Brazil
dc.description.affiliationUniv Fed Maranhao, Dept Pediat, Sao Luis, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Fac Med, Hosp Sao Lucas, Dept Pediat, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Estado Rio de Janeiro, Hosp Univ Pedro Ernesto, Dept Pediat, Rio De Janeiro, Brazil
dc.description.affiliationInst Med Integral Prof Fernando Figueira, Dept Pediat, Recife, PE, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Div Neonatol, Rio De Janeiro, Brazil
dc.description.affiliationUniv Estadual Londrina, Dept Pediat, Univ Hosp, Curitiba, Parana, Brazil
dc.description.affiliationHosp Estadual Diadema, Neonatal Unit, Diadema, Brazil
dc.description.affiliationUniv Fed Parana, Hosp Clin, Dept Pediat, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Div Neonatol, Belo Horizonte, MG, Brazil
dc.description.affiliationHosp Estadual Sumare, Neonatal Div, Sumare, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Div Neonatol, Botucatu, SP, Brazil
dc.format.extent1023-1032
dc.identifierhttp://dx.doi.org/10.1007/s00431-019-03386-9
dc.identifier.citationEuropean Journal Of Pediatrics. New York: Springer, v. 178, n. 7, p. 1023-1032, 2019.
dc.identifier.doi10.1007/s00431-019-03386-9
dc.identifier.issn0340-6199
dc.identifier.urihttp://hdl.handle.net/11449/184525
dc.identifier.wosWOS:000471701300007
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal Of Pediatrics
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHypothermia
dc.subjectPremature newborns
dc.subjectDeath
dc.subjectMorbidity
dc.titleAdmission hypothermia, neonatal morbidity, and mortality: evaluation of a multicenter cohort of very low birth weight preterm infants according to relative performance of the centeren
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0001-5292-2320[1]

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