In vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analogues

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dc.contributor.authorDieamant, Gustavo
dc.contributor.authorCosta, Adilson
dc.contributor.authorBechelli, Liliana
dc.contributor.authorTibério, Juliana [UNESP]
dc.contributor.authorPereira, Carolina
dc.contributor.institutionChemyunion Química Ltda.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionPontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
dc.contributor.institutionSpecialization in Cosmetics Safety Evaluation from the Vrije Universiteit
dc.contributor.institutionMantecorp Indústria Química e Farmacêutica Ltda.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionKOLderma Instituto de Pesquisa Clínica Ltda
dc.date.accessioned2014-05-27T11:27:24Z
dc.date.available2014-05-27T11:27:24Z
dc.date.issued2012-12-01
dc.description.abstractIntroduction: Aging skin is a condition that affects (or will affect) all people, and its treatment is considered a clinical challenge. Growth factors and their analogues are emerging as a promising therapeutic option. Objectives: To evaluate the safety profile of some dermocosmetic products with formulations based on growth factors - or their analogs intended for that purpose - using in vitro human skin cell culture models. Methods: Two types of cell cultures were studied, and the effects of the study products on the proliferation of melanoma cells and normal human fibroblasts were evaluated. Results: No significant morphological alterations were found in the cultured human melanoma, and no significant decrease in the number of healthy cells was verified in the normal fibroblasts culture. In some cases there was even a proliferation of those cells. Conclusions: These preliminary data demonstrate that cosmeceutical products containing growth factors as an active principle can be considered safe for topical application.en
dc.description.affiliationPharmacologist and immunotoxicologist physician Chemyunion Química Ltda., Sorocaba (SP)
dc.description.affiliationFaculdade de Medicina Universidade de São Paulo (USP), São Paulo (SP)
dc.description.affiliationUniversidade Federal de São Paulo Escola Paulista de Medicina (EPM/HSPA UNI), São Paulo (SP)
dc.description.affiliationCosmiatry, Pregnancy Dermatology, Vitiligo and Clinical Research Dermatology Outpatient Clinic of the Dermatology Service Universidade Católica de Campinas (PUC-Campinas), Campinas (SP)
dc.description.affiliationDermatologist physician; Member of the Brazilian Society of Dermatology Pediatrician physician; Member of the Brazilian Society of Pediatrics Specialization in Cosmetics Safety Evaluation from the Vrije Universiteit, Brussel
dc.description.affiliationMantecorp Indústria Química e Farmacêutica Ltda., São Paulo (SP)
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Botucatu (SP)
dc.description.affiliationR and D Department Chemyunion Química Ltda., Sorocaba (SP)
dc.description.affiliationDermatology Clinical Research intern KOLderma Instituto de Pesquisa Clínica Ltda, Campinas (SP)
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Botucatu (SP)
dc.format.extent229-236
dc.identifierhttp://www.surgicalcosmetic.org.br/detalhe-artigo/216/Avaliacao-in-vitro-do-perfil-de-seguranca-de-cosmeceuticos-contendo-fatores-de-crescimento-e-seus-analogos
dc.identifier.citationSurgical and Cosmetic Dermatology, v. 4, n. 3, p. 229-236, 2012.
dc.identifier.file2-s2.0-84872871156.pdf
dc.identifier.issn1984-5510
dc.identifier.issn1984-8773
dc.identifier.scopus2-s2.0-84872871156
dc.identifier.urihttp://hdl.handle.net/11449/74031
dc.language.isoeng
dc.relation.ispartofSurgical and Cosmetic Dermatology
dc.relation.ispartofsjr0,141
dc.relation.ispartofsjr0,141
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectIntercellular signaling peptides and proteins
dc.subjectSkin
dc.subjectSking aging
dc.titleIn vitro evaluation of the safety profile of cosmeceuticals containing growth factors and their analoguesen
dc.typeArtigo
dcterms.licensehttp://www.surgicalcosmetic.org.br/conteudo/7/termos-de-uso

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