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Polybioside, a Neuroactive Compound from the Venom of the Social Wasp Polybia paulista

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dc.contributor.authorSaidemberg, Daniel M. [UNESP]
dc.contributor.authorda Silva-Filho, Luiz C. [UNESP]
dc.contributor.authorCesar Tognoli, Lilian M. M. [UNESP]
dc.contributor.authorTormena, Claudio F.
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:55:25Z
dc.date.available2014-05-20T13:55:25Z
dc.date.issued2010-04-01
dc.description.abstractPolybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biosci, Lab Struct Biol & Zoochem,Dept Biol CEIS, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Chem, BR-17033360 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Chem, UNICAMP, BR-13084971 Campinas, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biosci, Lab Struct Biol & Zoochem,Dept Biol CEIS, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Chem, BR-17033360 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto de Investigação em Imunologia - Instituto Nacional de Ciência e Tecnologia (III-INCT)
dc.description.sponsorshipIdFAPESP: 04/07942-2
dc.description.sponsorshipIdFAPESP: 06/57122-6
dc.description.sponsorshipIdCNPq: 472870/2004-1
dc.format.extent527-531
dc.identifierhttp://dx.doi.org/10.1021/np900424t
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 73, n. 4, p. 527-531, 2010.
dc.identifier.doi10.1021/np900424t
dc.identifier.issn0163-3864
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19830
dc.identifier.wosWOS:000276950000003
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titlePolybioside, a Neuroactive Compound from the Venom of the Social Wasp Polybia paulistaen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0002-1508-0694[4]
unesp.author.orcid0000-0002-7363-8211[5]
unesp.author.orcid0000-0001-6674-2160[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.departmentBiologia - IBpt

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Rio Claro - IB - Instituto de Biociências