Effects of fluoride intake on insulin sensitivity and insulin signal transduction

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dc.contributor.authorChehoud, Keila Aziz [UNESP]
dc.contributor.authorChiba, Fernando Yamamoto [UNESP]
dc.contributor.authorSassaki, Kikue Takebayashi [UNESP]
dc.contributor.authorGarbin, Clea Adas Saliba [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:13Z
dc.date.accessioned2014-05-20T13:43:02Z
dc.date.available2013-09-30T18:29:13Z
dc.date.available2014-05-20T13:43:02Z
dc.date.issued2008-10-01
dc.description.abstractForty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.en
dc.description.affiliationSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Child & Social Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dent Sch Aracatuba, Dept Child & Social Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 05/53301-1
dc.format.extent270-275
dc.identifierhttp://www.fluorideresearch.org/414/files/FJ2008_v41_n4_p00i-0iv.pdf
dc.identifier.citationFluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.
dc.identifier.issn0015-4725
dc.identifier.lattes7239471016654133
dc.identifier.lattes8275401688702343
dc.identifier.lattes4419158525709686
dc.identifier.orcid0000-0001-5069-8812
dc.identifier.urihttp://hdl.handle.net/11449/14977
dc.identifier.wosWOS:000263901900003
dc.language.isoeng
dc.publisherInt Soc Fluoride Research
dc.relation.ispartofFluoride
dc.relation.ispartofjcr1.438
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectInsulin receptor substrateen
dc.subjectInsulin sensitivityen
dc.subjectInsulin signalen
dc.subjectPlasma fluorideen
dc.subjectRats and insulinen
dc.titleEffects of fluoride intake on insulin sensitivity and insulin signal transductionen
dc.typeArtigo
dcterms.rightsHolderInt Soc Fluoride Research
unesp.author.lattes7239471016654133
unesp.author.lattes8275401688702343
unesp.author.lattes4419158525709686[4]
unesp.author.orcid0000-0001-5069-8812[4]
unesp.author.orcid0000-0003-4406-405X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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