Artigos - Odontologia Infantil e Social - FOA

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  • ItemResenha
    Systematic review: Impact of parental decision on paediatric COVID-19 vaccination
    (2023-01-01) Garbin, Artênio José Ísper [UNESP]; Chiba, Erika Kiyoko [UNESP]; Garbin, Cléa Adas Saliba [UNESP]; Chiba, Fernando Yamamoto [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Saliba, Tânia Adas [UNESP]; Universidade Estadual Paulista (UNESP)
    Objective: The objective was to carry out a systematic review on the acceptance of parents to vaccinate their children against COVID-19 and the factors that contribute for vaccination hesitancy. Methods: The Preferred Reporting Items for Systematic Re- views and Meta-Analyses (PRISMA) guidelines and the Patient, Intervention, Comparison and Outcome (PICO) strategy were followed. A search was carried out in the VHL Regional Portal, PubMed, Scielo, Web of Science, Embase and Scopus databases. We included articles that assessed the rate of acceptance and/or hesitation of parents and the factors that affect the decision about vaccination against COVID-19 for their children in cross-sectional studies. Laboratory studies, animal models, tests and case reports that elected other aspects related to COVID-19 were excluded. The methodological quality of the studies was based on the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data, developed by the Joanna Briggs Institute. Results: From the 708 articles found, 237 studies remained after removal of duplicates. Titles and abstracts of these publications were evaluated and, applying the exclusion criteria, 56 articles were selected. Inclusion criteria were employed and 28 studies were eligible. Overall average vaccination acceptance rate was 55.81%, and the main reasons for vaccine hesitancy were uncertainty of vaccine efficacy and safety, concerns about side effects, and lack of access to relevant information. Conclusion: The research results can be useful for the development of health education and parental awareness strategies in order to promote greater adherence to vaccination against COVID-19.
  • ItemArtigo
    Primary Healthcare reconditioning to face the COVID-19 pandemic, and perception by professionals of the measures implemented in a Brazilian district
    (2023-04-01) Nascimento, Carolina Carvalho Menez Pinto [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Saliba, Tânia Adas [UNESP]; Garbin, Cléa Adas Saliba [UNESP]; Saliba, Nemre Adas [UNESP]; Universidade Estadual Paulista (UNESP)
    Objective: to describe the Primary Care (PC) scenario regarding reconditioning, equipment and organization of services in order to face the pandemic and to measure the perception by professionals regarding these adaptations. Method: a research with mixed method in a city of the San Pablo state (Brazil). In the quantitative stage, a descriptive cross-sectional study was conducted in 222 PC professionals; the adapted Risk assessment and management of exposure of health care workers in the context of COVID-19 questionnaire by the World Health Organization was implemented. This was followed by the qualitative approach, which consisted in field observation in four PC units. Results: out of the total, 86.94% (n= 193) mentioned that there was an assessment of the signs and symptoms of the users before consultation; 63.96% (n=142) stated that a daily cleaning routine was followed in the waiting room; 92.34% (n= 205) claimed that there were methods available for hand hygiene; 77.48% (n= 172) said that appointments were scheduled in order to maintain physical distancing; 80.12% (n= 178) had not conducted any reconditioning work, and 45.95% (n=102) provided educational materials to users. Conclusions: during field observation, some assessments for signs and symptoms in users were detected; no cleaning actions were observed in the units, it was perceived that there was not enough alcohol gel in the dispenser, there were no marks on the floor to keep distancing, there was a lack of educational materials, and it was not verified that any reconditioning work had been conducted. During data integration, there was convergence regarding physical structure and unit reconditioning.
  • ItemArtigo
    In vitro effect of low-fluoride toothpaste supplemented with sodium trimetaphosphate, xylitol, and erythritol on enamel demineralization
    (2023-01-01) Oliveira, Letícia Gonçalves [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Gonçalves, Francyenne Maira Castro [UNESP]; Fernandes, Gabriela Leal Peres [UNESP]; Cannon, Mark L.; Danelon, Marcelle [UNESP]; Universidade Estadual Paulista (UNESP); Ann and Robert Lurie Children's Hospital; Faculdade de Odontologia
    Regular use of toothpaste with fluoride (F) concentrations of ≥ 1000 ppm has been shown to contribute to reducing caries increment. However, when used by children during the period of dental development, it can lead to dental fluorosis. Objective: In this study, we aimed to evaluate the in vitro effect of a toothpaste formulation with reduced fluoride (F) concentration (200 ppm) supplemented with sodium trimetaphosphate (TMP: 0.2%), Xylitol (X:16%), and Erythritol (E: 4%) on dental enamel demineralization. Methodology: Bovine enamel blocks were selected according to initial surface hardness (SHi) and then divided into seven experimental toothpaste groups (n=12). These groups included 1) no F-TMP-X-E (Placebo); 2) 16% Xylitol and 4% Erythritol (X-E); 3) 16% Xylitol, 4% Erythritol and 0.2%TMP (X-E-TMP); 4) 200 ppm F (no X-E-TMP: (200F)); 5) 200 ppm F and 0.2% TMP (200F-TMP); 6) 200 ppm F, 16% Xylitol, 4% Erythritol, and 0.2% TMP (200F-X-E-TMP); and 7) 1,100 ppm F (1100F). Blocks were individually treated 2×/day with slurries of toothpastes and subjected to a pH cycling regimen for five days (DES: 6 hours and RE: 18 hours). Then, the percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), fluoride (F), calcium (Ca), and phosphorus (P) in enamel were determined. The data were analyzed by ANOVA (1-criterion) and the Student-Newman-Keuls test (p<0.001). Results: We found that the 200F-X-E-TMP treatment reduced %SH by 43% compared to the 1100F treatments (p<0.001). The ΔKHN was ~ 65% higher with 200F-X-E-TMP compared to 1100F (p<0.001). The highest concentration of F in enamel was observed on the 1100F treatment (p<0.001). The 200F-X-E-TMP treatment promote higher increase of Ca and P concentration in the enamel (p<0.001). Conclusion: The association of 200F-X-E-TMP led to a significant increase of the protective effect on enamel demineralization compared to the 1100F toothpaste.
  • ItemArtigo
    The Activity of Calcium Glycerophosphate and Fluoride against Cariogenic Biofilms of Streptococcus mutans and Candida albicans Formed In Vitro
    (2023-02-01) Cavazana, Thamires Priscila [UNESP]; Hosida, Thayse Yumi [UNESP]; Sampaio, Caio [UNESP]; de Morais, Leonardo Antônio [UNESP]; Monteiro, Douglas Roberto [UNESP]; Pessan, Juliano Pelim [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Universidade Estadual Paulista (UNESP); University of Western São Paulo (UNOESTE)
    This study evaluated the effects of calcium glycerophosphate (CaGP), with or without fluoride (F), on dual-species biofilms of Streptococcus mutans and Candida albicans. The biofilms were treated three times with 0.125, 0.25, and 0.5% CaGP solutions, with or without 500 ppm F (NaF). Additionally, 500 and 1100 ppm F-solutions and artificial saliva served as controls. After the final treatment, the microbial viability and biofilm structure, metabolic activity, total biomass production, and the composition of the extracellular matrix composition were analyzed. Regardless of the presence of F, 0.25 and 0.5% CaGP promoted a higher biomass production and metabolic activity increase than the controls (p < 0.05). F-free CaGP solutions reduced bacterial cell population significantly more than the 500 ppm F group or the negative control (p < 0.05). All the groups reduced the proteins, and 0.5% CaGP combined with F led to the highest reduction in the carbohydrate and nucleic acids content of the extracellular matrix (p < 0.05). It can be concluded that CaGP alone affected the number of bacterial cells and, when combined with F, reduced its production of biomass, metabolic activity, and the expression of the extracellular matrix components.
  • ItemArtigo
    Activity of Sodium Trimetaphosphate Nanoparticles on Cariogenic-Related Biofilms In Vitro
    (2023-01-01) Amarante, Viviane de Oliveira Zequini [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Sampaio, Caio [UNESP]; de Morais, Leonardo Antônio [UNESP]; de Camargo, Emerson Rodrigues; Monteiro, Douglas Roberto [UNESP]; Pessan, Juliano Pelim [UNESP]; Hosida, Thayse Yumi [UNESP]; Universidade Estadual Paulista (UNESP); Universidade Federal de São Carlos (UFSCar); University of Western São Paulo (UNOESTE)
    In light of the promising effect of sodium trimetaphosphate nanoparticles (TMPn) on dental enamel, in addition to the scarce evidence of the effects of these nanoparticles on biofilms, this study evaluated the activity of TMPn with/without fluoride (F) on the pH, inorganic composition and extracellular matrix (ECM) components of dual-species biofilms of Streptococcus mutans and Candida albicans. The biofilms were cultivated in artificial saliva in microtiter plates and treated with solutions containing 1% or 3% conventional/microparticulate TMP (TMPm) or TMPn, with or without F. After the last treatment, the protein and carbohydrate content of the ECM was analyzed, and the pH and F, calcium (Ca), phosphorus (P), and TMP concentrations of the biofilms were determined. In another set of experiments, after the last treatment, the biofilms were exposed to a 20% sucrose solution, and their matrix composition, pH, and inorganic component contents were evaluated. 3% TMPn/F significantly reduced ECM carbohydrate and increased biofilm pH (after sucrose exposure) than other treatments. Also, it significantly increased P and F levels before sucrose exposure in comparison to 3% TMPm/F. In conclusion, 3% TMPn/F affected the biofilm ECM and pH, besides influencing inorganic biofilm composition by increasing P and F levels in the biofilm fluid.
  • ItemArtigo
    In vitro dentin permeability and tubule occlusion of experimental in-office desensitizing materials
    (2023-03-01) de Castro Oliveira, Laryssa [UNESP]; Marchetti, Vitória Marega [UNESP]; de Souza e Silva Ramos, Fernanda [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Souza, Marina Trevelin; Ganss, Bernhard; Theodoro, Leticia Helena [UNESP]; Fagundes, Ticiane Cestari [UNESP]; Universidade Estadual Paulista (UNESP); Universidade Federal de São Carlos (UFSCar); University of Toronto
    Objectives: This study investigates the dentin permeability (by hydraulic conductance) and tubule occlusion (by confocal and scanning electron microscopies) of in-office desensitizing materials. Materials and methods: Bovine dentin blocks were immersed in EDTA to open dentinal tubules. Placebo varnish (PLA), fluoride varnish (FLU), NaF 5% + 5% nanoparticulate sodium trimetaphosphate varnish (TMP), universal adhesive system (SBU), S-PRG filler varnish (SPRG), Biosilicate (BIOS), and amelotin (AMTN) solution were the materials tested. After application, the specimens underwent an erosive-abrasive challenge. Dentin permeability was evaluated at T0 (initial), T1 (after treatment), and T2 (after challenge). Confocal and scanning electron microscopy (SEM) were used to evaluate, respectively, length and number of dentinal tubule occlusions and opened dentinal tubules, after challenge. Permeability and SEM data were analyzed by two-way repeated measures ANOVA and Tukey’s tests. Confocal data were analyzed by one-way ANOVA, Tukey’s test, and Kruskal–Wallis and Dunn’s tests. Spearman and Pearson’s correlation tests were also used. Significance level was set at 5%. Results: At T1, the AMTN group showed the lowest permeability value, following the increasing order at T2: AMTN = SBU < BIOS = SPRG < TMP < FLU < PLA. The SBU group had the highest value of occluded dentinal tubule length. The AMTN group presented more occluded dentinal tubules compared to PLA and FLU. AMTN and SBU had the lowest values of opened dentin tubules. Results showed a negative correlation between the analyses. Conclusion: The SBU and AMTN solution were more effective in reducing dentin permeability by occluding dentin tubules. Clinical relevance: All materials reduced permeability after challenge, except fluoride varnish.
  • ItemArtigo
    Impact in the integral health of the workers the area technology of the information who make home office during Covid-19
    (2022-01-01) Téllez, María Elizabeth Peña [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Garbin, Artênio José Isper [UNESP]; Saliba, Tânia Adas [UNESP]; Universidade Estadual Paulista (UNESP)
    Introduction: With the social isolation imposed by the Covid 19 pandemic, teleworking in the home office modality has been an alternative used by some companies. Objective: To determine the impact of this remote work on the integral health of workers. Methodology: A cross-sectional study was carried out, through the Google Forms platform, a semi-structured questionnaire was elaborated that was sent to 150 information technology workers from a medium-sized municipality in the state of São Paulo, to obtain information on the variables: age, sex, working conditions, oral and systemic health, oral hygiene habits, musculoskeletal pain, physical exercises and emotional state. Results: Of the total of 116 responses received, 87.07% belonged to the male sex, 100% reported concern with their oral and general health, 56.03% reported changes in their eating habits, 44.83% increased food consumption and 77.58% reported feeling concerned and anxious. The prevalence of painful musculoskeletal symptomatology manifested in 100% of workers predominantly found in the cervical region (53.44%). In general, low frequency of physical activity and inadequate conditions for home work performance were corroborated. Conclusions: The change from the usual work routine to the home office modality (teleworking) significantly impacted the health of information technology workers. Given the possibility of maintaining this modality of remote work to reduce the exposure and spread of the virus, it is necessary to adopt strategies to preserve the integral health of these professionals.
  • ItemArtigo
    Gels containing statherin-derived peptide protect against enamel and dentin erosive tooth wear in vitro
    (2023-01-01) Reis, Fabiana Navas; Francese, Monique Malta; Silva, Natara Dias Gomes da; Pelá, Vinicius Taioqui; Câmara, João Victor Frazão; Trevizol, Juliana Sanches; Pieretti, Joana Claudio; Seabra, Amedea Barozzi; Pessan, Juliano Pelim [UNESP]; Honório, Heitor Marques; Crusca, Edson [UNESP]; Marchetto, Reinaldo [UNESP]; Buzalaf, Marília Afonso Rabelo; Universidade de São Paulo (USP); Federal University of ABC; Universidade Estadual Paulista (UNESP)
    The effect of gels containing a statherin-derived peptide (Stn) on the protection against enamel and dentin erosive tooth wear (ETW) in vitro was evaluated. Bovine enamel and dentin specimens were divided into 2 groups (n = 15 and 18/group for enamel and dentin, respectively) that were treated with Chitosan or Carboxymethylcellulose (CMC) gels containing Stn15pSpS at 1.88 × 10-5 M or 3.76 × 10-5 M. Chitosan or CMC gels without active ingredients served as negative controls, while chitosan gel containing 1.23% F (as NaF) and acidulated phosphate fluoride gel (1.23% F) served as positive controls. The gels were applied on the specimens for 4 min. Stimulated saliva was collected from 3 donors and used to form a 2-h acquired pellicle on the specimens. Then, the specimens were submitted to an erosive pH cycling protocol 4 times/day for 7 days (0.01 M HCl pH 2.0/45 s, artificial saliva/2 h, and artificial saliva overnight). The gels were applied again during pH cycling, 2 times/day for 4 min after the first and last erosive challenges. Enamel and dentin loss (μm) were assessed by contact profilometry. Scanning electron microscopy (SEM) was analyzed using a cold field emission. Data were analyzed by two-way ANOVA (for chitosan and CMC gels, separately) and Tukey's multiple comparison test. SEM images showed changes to enamel topography after application oft the gels containing Stn or F. Regarding CMC-based gels, for enamel, none of the treatments significantly reduced ETW in comparison with placebo; for dentin, however, gels containing Stn, regardless the concentration, significantly reduced the ETW. Moreover, Chitosan-based gels, regardless the Stn concentration, were able to protect enamel and dentin against ETW. Gels containing Stn might be a new approach to protect against ETW.
  • ItemArtigo
    Effect of Fluoride on the Sensitivity and Secretion of Insulin
    (Royal Soc Chemistry, 2015-01-01) Lombarte, Mercedes; Rigalli, Alfredo; Chiba, Fernando Yamamoto [UNESP]; Sumida, Doris Hissako [UNESP]; Preedy, V. R.; Rosario Natl Univ; Universidade Estadual Paulista (UNESP)
  • ItemArtigo
    Topical Use of Fluorides for Caries Control
    (Karger, 2011-01-01) Pessan, Juliano Pelim [UNESP]; Toumba, Kyriacos Jack; Rabelo Buzalaf, Marilia Afonso; Buzalaf, MAR; Universidade Estadual Paulista (UNESP); Universidade de São Paulo (USP); Univ Leeds
    Since the early findings on the protective effects of fluoride present in drinking water upon caries incidence and prevalence, intensive research has been conducted in order to determine the benefits, safety, as well as the cost-effectiveness of other modalities of fluoride delivery. The present chapter reviews the various forms of topical fluoride use - professionally and self-applied - with special emphasis on clinical efficacy and possible side effects. The most widely used forms of fluoride delivery have been subject of several systematic reviews, providing strong evidence supporting the use of dentifrices, gels, varnishes and mouth rinses for the control of caries progression. Dentifrices with fluoride concentrations of 1,000 ppm and above have been shown to be clinically effective in caries prevention when compared to a placebo treatment, but the evidence regarding formulations with 450-550 ppm is still subject of debate. Therefore, the recommendation for low-fluoride dentifrice use must take into account both risks and benefits. The evidence for the combined use of two modalities of fluoride application in comparison to a single modality is still inconsistent, implying that more studies with adequate methodology are needed to determine the real benefits of each method. Considering the currently available evidence and risk-benefit aspects, it seems justifiable to recommend the use of fluoridated dentifrices to individuals of all ages, and additional fluoride therapy should also be targeted towards individuals at high caries risk. Copyright (C) 2011 S. Karger AG, Basel
  • ItemArtigo
    Historical and Recent Biological Markers of Exposure to Fluoride
    (Karger, 2011-01-01) Pessan, Juliano Pelim [UNESP]; Rabelo Buzalaf, Marilia Afonso; Buzalaf, MAR; Universidade Estadual Paulista (UNESP); Universidade de São Paulo (USP)
    Recent and historical biomarkers assess chronic or sub-chronic exposure to fluoride. The most studied recent biomarkers are nails and hair. Both can be non-invasively obtained, although collection of nails is more accepted by the subjects. External contamination may be a problem for both biomarkers and still needs to be better evaluated. Nails have been more extensively studied. Although the available knowledge does not allow their use as predictors of dental fluorosis by individual subjects, since reference values of fluoride have not yet been established, they have a strong potential for use in epidemiological surveys. Toenails should be preferred instead of fingernails, and variables that are known to affect nail fluoride concentrations - such as age, gender and geographical area -should be considered. The main historical biomarkers that could indicate total fluoride body burden are bone and dentin. Of these, bone is more studied, but its fluoride concentrations vary according to the type of bone and subjects' age and gender. They are also influenced by genetic background, renal function and remodeling rate, variables that complicate the establishment of a normal range of fluoride levels in bone that could indicate 'desirable' exposure to fluoride. The main issue when attempting to use bone as biomarker of fluoride exposure is the difficulty and invasiveness of sample collection. In this aspect, collection of dentin, especially from 3rd molars that are commonly extracted, is advantageous. However, mean values also span a wide range and reference concentrations have not been published yet. Copyright (C) 2011 S. Karger AG, Basel
  • ItemArtigo
    Effects of Sodium Hexametaphosphate and Fluoride on the pH and Inorganic Components of Streptococcus mutans and Candida albicans Biofilm after Sucrose Exposure
    (2022-08-01) Hosida, Thayse Yumi [UNESP]; Pessan, Juliano Pelim [UNESP]; Cavazana, Thamires Priscila [UNESP]; Sampaio, Caio [UNESP]; de Morais, Leonardo Antônio [UNESP]; Monteiro, Douglas Roberto [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Universidade Estadual Paulista (UNESP); University of Western São Paulo (UNOESTE)
    In order to improve the anticaries effects of fluoridated products, the supplementation of these products has been considered a promising alternative for caries control. This study evaluated the effects of sodium hexametaphosphate (HMP) and/or fluoride (F) on the inorganic components and pH of Streptococcus mutans and Candida albicans dual-species biofilms. The biofilms were treated 72, 78, and 96 h after the beginning of their formation with 0.25, 0.5, or 1% HMP-containing solutions with or without F (500 ppm, as sodium fluoride). F-containing solutions (500 ppm and 1100 ppm) and artificial saliva were used as controls. The biofilms were exposed to a 20% sucrose solution after the third treatment. Along with the biofilm pH, the concentrations of F, calcium, phosphorus (P), and HMP were determined. HMP, combined with F, increased F levels and decreased P levels in the biofilm fluid compared to that of the solution with 500 ppm F. Exposure to sucrose decreased the concentrations of all ions in the biomass, except for HMP; 1% HMP, combined with F, promoted the highest pH. It can be concluded that HMP affected the inorganic composition of the biofilm and exerted a buffering effect on the biofilm pH.
  • ItemArtigo
    Sickness absenteeism of Primary Health Care professionals before and during the COVID-19 pandemic
    (2022-01-01) Garbin, Artênio José Ísper [UNESP]; Nascimento, Carolina Carvalho Menez Pinto [UNESP]; Zacharias, Fabiana Costa Machado; Garbin, Cléa Adas Saliba [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Saliba, Nemre Adas [UNESP]; Universidade Estadual Paulista (UNESP); Universidade de São Paulo (USP)
    OBJECTIVE: to identify the frequency of occurrence of sickness absenteeism, according to the profile of Primary Health Care (PHC) professionals, and verify if there was an impact of the pandemic on absence duration and reason. METHODS: a cross-sectional study, from January/2019 to December/2020, with PHC professionals from a municipality in northeastern São Paulo. Descriptive statistics were performed, with frequency calculation. RESULTS: of the 977 PHC professionals, 633 (64.79%) used a medical certificate to justify their absence from work in 2019, and 837 (85.67%) in 2020. The main reason for leave was diseases of the musculoskeletal system and connective tissue in the two years. The mean duration of leave was 7.33 days (SD=17.33) in 2019 and 9.88 days (SD=16.05) in 2020. Nursing assistants were the ones who took the most leave in both years. CONCLUSIONS: there was an impact of the pandemic on absence duration and reason.
  • ItemArtigo
    Silver nanoparticles associated with a polyphosphate and fluoride enhance the prevention of enamel demineralization and impact on dual-biofilm adhesion
    (2022-10-01) Mendes-Gouvêa, Carla Corrêa [UNESP]; Danelon, Marcelle [UNESP]; Vieira, Ana Paula Miranda [UNESP]; do Amaral, Jackeline Gallo [UNESP]; de Souza Neto, Francisco Nunes [UNESP]; Gorup, Luiz Fernando; Camargo, Emerson Rodrigues; Delbem, Alberto Carlos Botazzo [UNESP]; Barbosa, Debora Barros [UNESP]; Universidade Estadual Paulista (UNESP); University of Ribeirão Preto - UNAERP; Federal University of Alfenas; Universidade Federal de São Carlos (UFSCar)
    Objectives: The aim of this study were to produce a multifunctional nanocomposite combining silver nanoaparticles (Ag), sodium trimetaphosphate (TMP) and fluoride (F), to investigate its effect on dental enamel demineralization and on biofilms of Streptococcus mutans and Candida albicans. Methods: Bovine enamel blocks were submitted to five pH cycles and treated 2x/day with 100 ppm F, 225 ppm F, 100 ppm F + 0.2%TMP or 100 ppm F + 0.2%TMP+10% Ag (100F/TMP/Ag). Next, surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), enamel fluoride (F) and calcium (Ca) concentration were determined. Biofilms from single and dual species of S. mutans and C. albicans were treated with 100F/TMP/Ag, Ag or chlorhexidine gluconate for 24 h. The antibiofilm effect was evaluated by colony-forming unit counting and Scanning Electron Microscopy. Results: The nanocomposite reduced 43.0% of %SH and was similar with samples treated with 225F, 100F/TMP and 100/TMP/Ag. The attribute of F and/or TMP in reducing ΔKHN in 5–20 μm was not affected by the addiction of Ag (110F = 225F = 100F/TMP = 100F/TMP/Ag > Negative Control). Further, 100F/TMP/Ag strongly reduced viable cells of S. mutans in dual biofilms (∼5 log10cm2) and structurally affected the biofilms. Conclusion: The 100F/TMP/F promoted a protective effect against enamel demineralization and was able to significantly inhibit the growth of biofilms of S. mutans and C. albicans. Clinical significance: The focus on prevention and non-invasive dental treatment is the most effective and least costly way to improve the population's oral health conditions. We present a nanocomposite for a multiple approach in prevention of caries.
  • ItemArtigo
    The effect of toothpaste with reduced concentration of fluoride-containing sodium trimetaphosphate and polyols on initial enamel erosion
    (2022-01-01) de Toledo, Priscila Toninatto Alves [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Cannon, Mark Lloyd; Sakamoto, Amanda Eliane [UNESP]; Pedrini, Denise [UNESP]; Universidade Estadual Paulista (UNESP); Ann and Robert Lurie Children’s Hospital
    Objectives: This in vitro study evaluated the efficacy of toothpaste containing fluoride (F), sodium trimetaphosphate (TMP), and xylitol and erythritol (XE) to inhibit or repair initial enamel erosion lesions. Materials and methods: Bovine enamel blocks (n = 120) were selected according to surface hardness (SH) and randomly divided into 5 experimental groups (n = 24 blocks/group): Placebo (no F, TMP, XE); 1100 ppm F; 16% xylitol + 4% erythritol (XE); 200 ppm F + 0.2% TMP (200 ppm F/TMP); and 200 ppm F + 0.2% TMP + 16% xylitol + 4% erythritol (200 ppm F/TMP/XE). The sound and softened blocks were immersed in toothpaste slurry in human saliva for 2 min. The blocks were then submitted to 4 erosive challenges in citric acid (0.75%, pH 3.5), each challenge for 1 min, with stirring. The SH of the blocks was determined after treatment (t) and after the 4 erosive challenges. In addition, the precipitates were analyzed by scanning electron microscopy (SEM). Variables were submitted to a two-way repeated-measures analysis of variance followed by a Student–Newman–Keuls test (p < 0.05). Results: Toothpaste containing 200 ppm F/TMP/XE led to the highest protective and repair effect compared to the other groups (p < 0.001). The protective and repair effect was XE > 200 ppm F/TMP > 1100 ppm F > placebo (p < 0.001). All groups produced precipitates with a thicker layer for XE and TMP groups. Conclusions: Toothpaste containing 200 ppm F, TMP, and polyols demonstrated a superior protective and repair effect in initial enamel erosive lesions in vitro. Clinical relevance: Toothpaste containing F and polyols could be an advantage in patients affected by dental erosion, due to its higher preventive potential, mainly in individuals who frequently drink acidic beverages. However, future studies are needed to confirm these results.
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    Malocclusion and its relationship with oral health-related quality of life in patients with eating disorders
    (2022-01-01) Chiba, Fernando Yamamoto [UNESP]; Chiba, Erika Kiyoko [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Matsushita, Doris Hissako [UNESP]; Garbin, Artênio José Ísper [UNESP]; Garbin, Cléa Adas Saliba [UNESP]; Universidade Estadual Paulista (UNESP)
    Objective: To evaluate the prevalence and severity of mal-occlusion and its impact on oral health-related quality of life (OHRQoL) and self-reported satisfaction of patients with anorexia and bulimia nervosa. Methods: The sample consisted of sixty women who attended a specialized mental health clin-ic of a Brazilian medical school. Participants were distribut-ed into two groups: patients with anorexia and bulimia nervosa (ABN; n=30) and control patients without eating disorders (CN; n=30). The dental occlusion was evaluated by the Dental Aesthetic Index; the OHRQoL was assessed using the OHIP-14 questionnaire; and the self-reported satisfaction with the appearance of teeth, speech ability and chewing was obtained by interviews. Results: Severe and very severe malocclusion were observed in 26.67% and 46.67% of patients in the ABN group, respectively, while the CN group showed 80.00% of patients without abnormality/mild malocclusion. ABN group showed a higher proportion of patients (p < 0.05) with tooth loss, spacing in the region of incisors, maxillary misalignment, and mandibular misalignment in relation to CN group. ABN group presented lower (p < 0.05) OHRQoL and self-reported satisfaction with the appearance of teeth, speech ability and chewing, com-pared to the CN group. There was a significant positive correlation (p < 0.05) between the Dental Aesthetic Index and OHIP-14 scores in the ABN group. Conclusions: The prevalence of severe malocclusion in ABN group was high, with a negative impact on OHRQoL and self-reported satisfaction with the chewing ability, speech ability and appearance of teeth.
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    Condição de saúde bucal e acesso aos serviços odontológicos em idosos atendidos em um hospital municipal da área rural de Benguela, Angola
    (Universidade do Estado do Rio Janeiro, 2022-03-25) Caconda, Laurinda Luísa Isaias [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Saliba, Nemre Adas [UNESP]; Chiba, Fernando Yamamoto [UNESP]; Saliba, Tânia Adas [UNESP]; Universidade Estadual Paulista (UNESP)
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    Self-perception of oral health among tertiary-care users: quanti-qualitative analysis with chronic kidney disease patients
    (2022-01-14) Amaral, Marcelo Augusto; Miotto, Aline Maria Malachini; Moimaz, Suzely Adas Saliba [UNESP]; Garbin, Cléa Adas Saliba [UNESP]; Centro Universitário de Maringá; Universidade Estadual de Maringá (UEM); Universidade Estadual Paulista (UNESP)
    Chronic kidney disease (CKD) has become a global public health challenge. The objective of this study was to analyze the relationship between self-perception of oral health and clinical condition among patients with CKD. This is a quanti-qualitative survey conducted in a CKD specialized service. The sample consisted of 60 patients who underwent oral examinations to have their severity of caries (DMFT) and need for dental prosthesis checked. Age, sex, time on dialysis, marital status, skin color, education and pre-existing diseases were also analyzed. Among the kidney patients who agreed to undergo the clinical examinations and showed communication skills, some were selected, and three focus groups were created, with the participation of a moderator and six to 10 kidney patients in each group. Their speeches were processed in the IRAMUTEQ software and analyzed through the similarity analysis and word cloud techniques. As for profile, the patients were aged 60.23 ± 10.87 years old; were male (73.33%); were on dialysis for 41.90 ± 56.57 months; were married (61.67%); were white (76.67%); had incomplete primary education (41.66%); had arterial hypertension (76.67%); had a DMFT index of 22.55 ± 8.39; 43.33% needed an upper complete denture; and 30.00% needed a lower complete denture. The similarity analysis revealed many doubts and uncertainties about current health services, which can be proven by the words ‘no’ and ‘treatment’. The quanti-qualitative analysis showed a high rate of dental loss and the need for complete dentures and suggests inequities in oral health care for chronic kidney disease patients, especially in tertiary care. There was a positive representation regarding oral health, but the lexicographical analyses of the textual corpus confirmed the self-perception of lack of dental care.
  • ItemArtigo
    Novel pulp capping material based on sodium trimetaphosphate: synthesis, characterization, and antimicrobial properties
    (2022-01-01) Franzin, Nayara Rodrigues Sartori [UNESP]; Sostena, Michela Melissa Duarte Seixas [UNESP]; Santos, Alailson Domingos Dos; Moura, Marcia Regina [UNESP]; Camargo, Emerson Rodrigues de; Hosida, Thayse Yumi [UNESP]; Delbem, Alberto Carlos Botazzo [UNESP]; Moraes, João Carlos Silos [UNESP]; Universidade Estadual Paulista (UNESP); RS; Universidade Federal de São Carlos (UFSCar)
    OBJECTIVES: To evaluate the mechanical, physicochemical, and antimicrobial properties of four different formulations containing micro- or nanoparticles of sodium trimetaphosphate (mTMP and nTMP, respectively). METHODOLOGY: Four experimental groups were used in this investigation: two mTMP groups and two nTMP groups, each containing zirconium oxide (ZrO2), and solution containing either chitosan or titanium oxide (TiO2) nanoparticles (NPs). Setting time, compression resistance, and radiopacity were estimated. The agar diffusion test was used to assess the antimicrobial activity of the formulations against five different microbial strains: Streptococcus mutans, Lactobacillus casei, Actinomyces israelii, Candida albicans, and Enterococcus faecalis. Parametric and nonparametric tests were performed after evaluating homoscedasticity data (p<0.05). RESULTS: From the properties evaluated, nTMP cements required less setting time and showed greater resistance to compression. Cements containing TiO2 showed greater radiopacity for both nTMP and mTMP. All four cement formulations showed antimicrobial activity against S. mutans and L. casei. CONCLUSION: Formulations containing nTMP have shorter setting times and higher compressive strength, and those with TiO2 nanoparticles showed antimicrobial activities. Clinical relevance: The cement containing nTMP, ZrO2, and TiO2 could be an alternative material for protecting the pulp complex.
  • ItemArtigo
    Analysis of the Dental Caries Epidemiological Profile in Children of Benguela city, Angola
    (2022-01-01) Songa, Marcial António Simão [UNESP]; Saliba, Nemre Adas [UNESP]; Saliba, Tânia Adas [UNESP]; Chiba, Fernando Yamamoto [UNESP]; Moimaz, Suzely Adas Saliba [UNESP]; Universidade Estadual Paulista (UNESP)
    Purpose: To analyse the epidemiological profile of dental caries in children aged 5 and 12 years in the city of Ben guela, Angola. Materials and Methods: This was an observational, analytical, cross-sectional study conducted in 2019 with 190 12-year-old schoolchildren and 240 5-year-old schoolchildren from the public education system in Benguela, An gola. The relationship between dental caries and dental characteristics, sociodemographic factors, access to den tal services, oral hygiene practices, and eating habits was analysed. Dental condition was evaluated using the dmft and decayed, missing, and filled teeth (DMFT) indices. Results It was found that 62.63% (n = 119) of 12-year-old students and 42.08% (n 101) of 5-year-old students were free from dental caries. The average DMFT was 0.76 + 1.35 and dmft was 2.19 + 2.95. The majority of chil dren (56.51%) had never been to the dentist, had no dental elements restored, and none of the students used dental floss. The proportion of students who consumed sweets every day was higher at 5 years of age (46.25%) than at 12 years of age (22.63%). There was a statistically significant association (P 0.01) between the higher in cidence of dental caries and peri-urban location among 5-year-old schoolchildren. Conclusion This study showed that the prevalence of dental caries in the permanent dentition of schoolchildren in Benguela is very low; however, the situation is critical in the primary dentition, especially in the peri-urban area. The limited access to dental surgeons and lack of treatment for affected teeth highlight the need to implement and de velop public policies to promote oral health.