In vitro antibacterial activity of ethanol extract of Artemisia annua and its bioactive fractions against fish pathogens

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dc.contributor.authorSoares, Michelly Pereira [UNESP]
dc.contributor.authorPinheiro, Victor Rossi
dc.contributor.authorCardoso, Israel Luz [UNESP]
dc.contributor.authorOliveira, Adriana da Silva Santos de
dc.contributor.authorSartoratto, Adilson
dc.contributor.authorIshikawa, Márcia Mayumi
dc.contributor.authorJonsson, Claudio Martin
dc.contributor.authorDuarte, Marta Cristina Teixeira
dc.contributor.authorRantin, Francisco Tadeu [UNESP]
dc.contributor.authorSampaio, Fernanda Garcia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCentro Universitário de Jaguariúna – UniFAJ
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2021-06-25T10:17:28Z
dc.date.available2021-06-25T10:17:28Z
dc.date.issued2021-04-01
dc.description.abstractBacterial pathogens cause significant economic losses in fish farms worldwide. The frequent use of antibiotics is a growing concern due to the adverse effects on human health and the environment. We evaluate the antibacterial activity of the Artemisia annua and its bioactive components against the Aeromonas hydrophila, Streptococcus agalactiae and Flavobacterium columnare, the main bacteria that affect fish culture. Bioactive components of the A. annua were obtained using an alcoholic extraction process, yielding 10.6% of dry material. The alcoholic extract of A. annua (ae-Aa) bioactive compounds was fractionated, obtaining the fractions F1 + 2, F3, F4, F5 and F6. Artemisinin up to 10.0 mg.ml-1 was ineffective in controlling studied bacteria. Microorganisms tested were all sensitive to ae-Aa (MIC and MBC 0.40 to 2.50 mg.ml-1). The ae-Aa components F3, F4, F5 and F6 were also effective (MIC and MBC 0.015 to 2.00 mg.ml-1). F3 showed the most effective antibacterial activity (MIC 0.015 to 0.5 mg.ml-1 and MBC 0.015 to 2.0 mg.ml-1). The ae-Aa and its bioactive components presented efficacy to inhibit growth and eliminate bacterial pathogens and can be an alternative to synthetic antibiotics for farmed fish.en
dc.description.affiliationJoint Graduate Program in Physiological Sciences Federal University of São Carlos-UFSCar/São Paulo State University UNESP
dc.description.affiliationCentro Universitário de Jaguariúna – UniFAJ
dc.description.affiliationBrazilian Agricultural Research Corporation - Embrapa Environment (EMBRAPA)
dc.description.affiliationChemical Biological and Agricultural Pluridisciplinary Research Center (CPQBA) Campinas State University (UNICAMP)
dc.description.affiliationUnespJoint Graduate Program in Physiological Sciences Federal University of São Carlos-UFSCar/São Paulo State University UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipEmpresa Brasileira de Pesquisa Agropecuária
dc.description.sponsorshipMinistério da Agricultura, Pecuária e Abastecimento
dc.format.extent1797-1801
dc.identifierhttp://dx.doi.org/10.1111/are.15026
dc.identifier.citationAquaculture Research, v. 52, n. 4, p. 1797-1801, 2021.
dc.identifier.doi10.1111/are.15026
dc.identifier.issn1365-2109
dc.identifier.issn1355-557X
dc.identifier.scopus2-s2.0-85097064294
dc.identifier.urihttp://hdl.handle.net/11449/205561
dc.language.isoeng
dc.relation.ispartofAquaculture Research
dc.sourceScopus
dc.subjectalcoholic extract
dc.subjectartemisinin
dc.subjectfish pathogenic bacteria
dc.subjectminimum bactericidal concentration
dc.subjectminimum inhibitory concentration
dc.titleIn vitro antibacterial activity of ethanol extract of Artemisia annua and its bioactive fractions against fish pathogensen
dc.typeArtigo
unesp.author.orcid0000-0002-6511-9454[10]

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