Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters

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dc.contributor.authorMartinello, F.
dc.contributor.authorSoares, S. M.
dc.contributor.authorFranco, J. J.
dc.contributor.authorSantos, A. C.
dc.contributor.authorSugohara, A.
dc.contributor.authorGarcia, S. B.
dc.contributor.authorCurti, C.
dc.contributor.authorUyemura, S. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:17:58Z
dc.date.available2014-05-20T13:17:58Z
dc.date.issued2006-06-01
dc.description.abstractDietary modifications may significantly reduce cardiovascular disease (CVD) risk factors, including cholesterol and atherosclerosis. The present study addressed the effects of the crude extract from the pulp fruit of Tamarindus indica L. on lipid serum levels and early atherosclerotic lesions in hypercholesterolemic hamsters in vivo, and the extract's antioxidant action, in vitro. Animals were fed on either chow or atherogenic diet during 10 weeks and concomitantly received either water or T indica L. extract for drinking. Treatment of hypercholesterolemic hamsters with the T. indica pulp fruit extract (5%) led to a decrease in the levels of serum total cholesterol (50%), non-HDL cholesterol (73%) and triglyceride (60%), and to an increase of high-density lipoprotein (HDL) cholesterol levels (61%). In vitro, the extract presented radical scavenging ability, as assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radicals assays, and led to decreased lipid peroxidation in serum, as assessed by the thiobarbituric acid reactive substances (TBARS) assay. In vivo, the extract improved the efficiency of the antioxidant defense system, as assessed by the superoxide dismutase, catalase and glutathione peroxidase activities. Together these results indicate the potential of tamarind extracts in diminishing the risk of atherosclerosis development in humans. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Patol, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Zootecn, Fac Ciências Agrarias & Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Zootecn, Fac Ciências Agrarias & Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.format.extent810-818
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2005.10.011
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 44, n. 6, p. 810-818, 2006.
dc.identifier.doi10.1016/j.fct.2005.10.011
dc.identifier.issn0278-6915
dc.identifier.lattes0950078741013951
dc.identifier.urihttp://hdl.handle.net/11449/4233
dc.identifier.wosWOS:000238552600003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecttamarindpt
dc.subjectTamarindus indica L.pt
dc.subjecthypercholesterolemic hamsterpt
dc.subjectantioxidant activitypt
dc.subjectfree radicalpt
dc.subjectatherosclerosispt
dc.titleHypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamstersen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0950078741013951
unesp.author.orcid0000-0001-8154-5595[7]
unesp.author.orcid0000-0001-9016-2027[4]
unesp.author.orcid0000-0001-5505-9817[8]
unesp.author.orcid0000-0003-1630-3543[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentZootecnia - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias