ONE-POT SYNTHESIS OF ISOQUINUCLIDINE DERIVATIVES THROUGH MULTICOMPONENT AZA-DIELS-ALDER REACTIONS PROMOTED BY NIOBIUM PENTAETHOXIDE
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2015-01-01
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Raman Publ
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The bicyclic isoquinuclidine system can be found in many natural products and has several pharmacological properties. In this paper is described an one-pot sysnthesis of Isoquinuclidine derivatives through multicomponent aza-Diels-Alder reactions between aniline derivatives, benzaldehyde and 2-cyclohexenone, promoted by niobium pentaethoxide under mild conditions, affording the expected products in high yields.
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Heterocyclic Letters. Jaipur: Raman Publ, v. 5, n. 3, p. 431-442, 2015.
