Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices

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dc.contributor.authorDeLucia, R.
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorFerreira, M. P.
dc.contributor.authorAizenstein, M. L.
dc.contributor.authorScavone, C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:13Z
dc.date.available2014-05-27T11:18:13Z
dc.date.issued1997-05-01
dc.description.abstractFencamfamine (FCF) is a central stimulant that facilitates central dopaminergic transmission through inhibition of dopamine uptake and enhanced release of the transmitter. We evaluated the changes in the inhibition of uptake and the release of striatal [ 3H]-dopamine at 9:00 and 21:00 h, times corresponding to maximal and minimal behavioral responses to FCF, respectively. Adult male Wistar rats (200-250 g) maintained on a 12-h light/12-h dark cycle (lights on at 7:00 h) were used. In the behavioral experiments the rats (N = 8 for each group) received FCF (3.5 mg/kg, ip) or saline at 9:00 or 21:00 h. Fifteen minutes after treatment the duration of activity (sniffing, rearing and locomotion) was recorded for 120 min. The basal motor activity was higher (28.6 ± 4.2 vs 8.4 ± 3.5 s) after saline administration at 21:00 h than at 9:00 h. FCF at a single dose significantly enhanced the basal motor activity (38.3 ± 4.5 vs 8.4 ± 3.5 s) and increased the duration of exploratory activity (38.3 ± 4.5 vs 32.1 ± 4.6 s) during the light, but not the dark phase. Two other groups of rats (N = 6 for each group) were decapitated at 9:00 and 21:00 h and striata were dissected for dopamine uptake and relase assays. The inhibition of uptake and release of [ 3H]-dopamine were higher at 9:00 than at 21:00 h, suggesting that uptake inhibition and the release properties of FCF undergo daily variation. These data suggest that the circadian time-dependent effects of FCF might be related to a higher susceptibility of dopamine presynaptic terminals to the action of FCF during the light phase which corresponds to the rats' resting period.en
dc.description.affiliationDepartamento de Farmacologia Inst. de Cie. Biomédicas Universidade de São Paulo, 05508-900 São Paulo, SP
dc.description.affiliationDepto. Principios Ativos, N. Faculdade de Cie. Farmaceuticas Universidade Estadual Paulista, 14801-902 Araraquara, SP
dc.description.affiliationUnespDepto. Principios Ativos, N. Faculdade de Cie. Farmaceuticas Universidade Estadual Paulista, 14801-902 Araraquara, SP
dc.format.extent637-640
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1997000500011
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 30, n. 5, p. 637-640, 1997.
dc.identifier.doi10.1590/S0100-879X1997000500011
dc.identifier.file2-s2.0-0030988290.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.scieloS0100-879X1997000500011
dc.identifier.scopus2-s2.0-0030988290
dc.identifier.urihttp://hdl.handle.net/11449/65098
dc.identifier.wosWOS:A1997WZ10200011
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectbehavior
dc.subjectchronopharmacology
dc.subjectdopamine release
dc.subjectdopamine uptake
dc.subjectfencamfamine
dc.subjectdopamine
dc.subjectfencamfamin
dc.subjectanimal experiment
dc.subjectcircadian rhythm
dc.subjectcontrolled study
dc.subjectcorpus striatum
dc.subjectdopaminergic transmission
dc.subjectdrug effect
dc.subjectintraperitoneal drug administration
dc.subjectnonhuman
dc.subjectpresynaptic nerve
dc.subjectrat
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectCentral Nervous System Stimulants
dc.subjectCircadian Rhythm
dc.subjectCorpus Striatum
dc.subjectDopamine
dc.subjectDopamine Antagonists
dc.subjectMale
dc.subjectNorbornanes
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectAnimalia
dc.subjectRattus norvegicus
dc.titleCircadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slicesen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm#Copyright
unesp.author.lattes2514762545280942[2]
unesp.author.orcid0000-0002-1378-6327[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas