Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis

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dc.contributor.authorFragoso, Mariana F. [UNESP]
dc.contributor.authorRomualdo, Guilherme R. [UNESP]
dc.contributor.authorRibeiro, Daniel A.
dc.contributor.authorBarbisan, Luis F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:30:05Z
dc.date.available2014-05-27T11:30:05Z
dc.date.issued2013-08-01
dc.description.abstractThis study investigated the protective effect of spray-dried açaí powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4. weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10. weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20. weeks, using colon tumors as the endpoint. In ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1-3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p=. 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p=. 0.042). In tumor assay, a reduction in the number of invasive tumors (p<. 0.005) and tumor multiplicity (p=. 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p=. 0.003) and net growth index (p=. 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. © 2013 Elsevier Ltd.en
dc.description.affiliationUNESP - Univ. Estadual Paulista School of Medicine, Botucatu 18618-970, SP
dc.description.affiliationUNESP - Univ. Estadual Paulista Institute of Biosciences Department of Morphology, Botucatu 18618-970, SP
dc.description.affiliationUNIFESP Federal University of Sao Paulo Department of Biosciences, 11060-001 Santos, SP
dc.description.affiliationUnespUNESP - Univ. Estadual Paulista School of Medicine, Botucatu 18618-970, SP
dc.description.affiliationUnespUNESP - Univ. Estadual Paulista Institute of Biosciences Department of Morphology, Botucatu 18618-970, SP
dc.format.extent68-76
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2013.04.011
dc.identifier.citationFood and Chemical Toxicology, v. 58, p. 68-76.
dc.identifier.doi10.1016/j.fct.2013.04.011
dc.identifier.file2-s2.0-84877654261.pdf
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.scopus2-s2.0-84877654261
dc.identifier.urihttp://hdl.handle.net/11449/76129
dc.identifier.wosWOS:000322099100010
dc.language.isoeng
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAberrant crypt foci
dc.subjectAçaí pulp
dc.subjectColon carcinogenesis
dc.subjectSpray-dry
dc.subjectacetylcysteine
dc.subjectbeta catenin
dc.subjectcaspase 3
dc.subjectconnexin 43
dc.subjectdimethylhydrazine
dc.subjectEuterpe oleracea extract
dc.subjectKi 67 antigen
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectArecaceae
dc.subjectcancer inhibition
dc.subjectcell proliferation
dc.subjectcolon cancer
dc.subjectcolon carcinogenesis
dc.subjectcontrolled study
dc.subjectEuterpe oleracea
dc.subjectfluid intake
dc.subjectfood intake
dc.subjectintestine crypt
dc.subjectmale
dc.subjectnonhuman
dc.subjectpowder
dc.subjectprotein expression
dc.subjectrat
dc.subjectspray drying
dc.subjecttreatment duration
dc.subjecttumor growth
dc.subjectweight gain
dc.titleAçai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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