Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis

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Fragoso, Mariana F. [UNESP]
Romualdo, Guilherme R. [UNESP]
Ribeiro, Daniel A.
Barbisan, Luis F. [UNESP]

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This study investigated the protective effect of spray-dried açaí powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4. weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10. weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20. weeks, using colon tumors as the endpoint. In ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1-3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p=. 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p=. 0.042). In tumor assay, a reduction in the number of invasive tumors (p<. 0.005) and tumor multiplicity (p=. 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p=. 0.003) and net growth index (p=. 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. © 2013 Elsevier Ltd.



Aberrant crypt foci, Açaí pulp, Colon carcinogenesis, Spray-dry, acetylcysteine, beta catenin, caspase 3, connexin 43, dimethylhydrazine, Euterpe oleracea extract, Ki 67 antigen, plant extract, unclassified drug, animal cell, animal experiment, animal model, animal tissue, apoptosis, Arecaceae, cancer inhibition, cell proliferation, colon cancer, colon carcinogenesis, controlled study, Euterpe oleracea, fluid intake, food intake, intestine crypt, male, nonhuman, powder, protein expression, rat, spray drying, treatment duration, tumor growth, weight gain

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Food and Chemical Toxicology, v. 58, p. 68-76.