Açai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis
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2013-08-01
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This study investigated the protective effect of spray-dried açaí powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4. weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5% or 5.0% AP or a diet containing 0.2% N-acetylcysteine (NAC) for 10. weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0% AP for 20. weeks, using colon tumors as the endpoint. In ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1-3 AC) were observed in the groups fed with 5.0% AP (37% AC and 47% ACF inhibition, p=. 0.036) and 0.2% NAC (39% AC and 41% ACF inhibition, p=. 0.042). In tumor assay, a reduction in the number of invasive tumors (p<. 0.005) and tumor multiplicity (p=. 0.001) was observed in the group fed with 5.0% AP. Also, a reduction in tumor Ki-67 cell proliferation (p=. 0.003) and net growth index (p=. 0.001) was observed in the group fed with 5.0% AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis. © 2013 Elsevier Ltd.
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Aberrant crypt foci , Açaí pulp , Colon carcinogenesis , Spray-dry , acetylcysteine , beta catenin , caspase 3 , connexin 43 , dimethylhydrazine , Euterpe oleracea extract , Ki 67 antigen , plant extract , unclassified drug , animal cell , animal experiment , animal model , animal tissue , apoptosis , Arecaceae , cancer inhibition , cell proliferation , colon cancer , colon carcinogenesis , controlled study , Euterpe oleracea , fluid intake , food intake , intestine crypt , male , nonhuman , powder , protein expression , rat , spray drying , treatment duration , tumor growth , weight gain
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Food and Chemical Toxicology, v. 58, p. 68-76.