Mutagenicity of paepalantine dimer and glycoside derivatives from Paepalanthus bromelioides

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dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorDevienne, K. F.
dc.contributor.authorRaddi, MSG
dc.contributor.authorFuruya, E. M.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:30Z
dc.date.available2014-05-20T13:24:30Z
dc.date.issued2004-02-01
dc.description.abstractThe first isocoumarin isolated from the methylene chloride extract of Paepalanthus bromelioides, named paepalantine (isocoumarin 1), was found to have antimicrobial activity; but, it is mutagenic clastogenic and cytotoxic. Two other isocoumarins, paepalantine-9-O-beta-D-glucopyranoside (isocoumarin 2) and paepalantine-9-O-beta-D-allopyranosyl(1-->6) glucopyranoside (isocoumarin 3) were isolated from the ethanolic extract. A fourth new isocoumarin, also isolated from the methylene chloride extract of the capitula of P. bromelioides, was characterized as an 8-8' dimer of paepalantine and denominated isocoumarin 4. The abilities of isocoumarins 2, 3 and 4 to induce mutations in Salmonella typhimurium strains TA97a, TA98, TA100 and TA102 were investigated. Mutagenic activity was observed in strain TA97a treated with isocoumarin 2 in the presence of S9 mixture. The substitution of H at position 9 by glucose or glucose-allose caused reductions in the mutagenic activities of paepalantine, indicating this to be an important site for these properties. (C) 2003 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Chem Inst Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Chem Inst Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.format.extent109-114
dc.identifierhttp://dx.doi.org/10.1016/j.tiv.2003.07.002
dc.identifier.citationToxicology In Vitro. Oxford: Pergamon-Elsevier B.V., v. 18, n. 1, p. 109-114, 2004.
dc.identifier.doi10.1016/j.tiv.2003.07.002
dc.identifier.issn0887-2333
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7613
dc.identifier.wosWOS:000188058900013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicology in Vitro
dc.relation.ispartofjcr3.105
dc.relation.ispartofsjr0,931
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectisocoumarinspt
dc.subjectmutagenicitypt
dc.subjectSalmonella typhimuriumpt
dc.titleMutagenicity of paepalantine dimer and glycoside derivatives from Paepalanthus bromelioidesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0003-3032-2556[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas