Relationship between physical activity practice and metabolic profile of postmenopausal women under treatment with aromatase inhibitors for breast cancer

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dc.contributor.authorde Paulo, Thais R.S. [UNESP]
dc.contributor.authorViezel, Juliana [UNESP]
dc.contributor.authorAro, Bruna L. [UNESP]
dc.contributor.authorSeidinger, Sylvia C. [UNESP]
dc.contributor.authorTrindade, Ana Carolina A.C. [UNESP]
dc.contributor.authorChristofaro, Diego G.D. [UNESP]
dc.contributor.authorFreitas, Ismael F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Amazonas (UFAM)
dc.date.accessioned2018-12-11T16:48:07Z
dc.date.available2018-12-11T16:48:07Z
dc.date.issued2017-09-01
dc.description.abstractObjective To analyze the relationship between physical activity practice and metabolic profile of postmenopausal women under treatment with aromatase inhibitors (AIs) for the treatment of breast cancer. Study design Cross-sectional study, conducted with 101 postmenopausal women (aged 50–80 years). The sample was divided into two groups; group without cancer (GW; n = 65) and breast cancer group treated with AIs (GC; n = 36). Physical activity (PA) was evaluated by questionnaire. Correlations between physical activity and metabolic variables were made by Pearson's correlation coefficient and the magnitude of these relationships by linear regression. Results In GW, there were observed significant inverse correlations between physical activity and VLDL cholesterol (β = −0.036; 95% CI = −0.068; −0.004); triglycerides (β = −0.036; 95% CI = −0.015; −0.002); glycose (β = −0.029; 95% CI = −0.047; −0.012); and C-reactive protein (β = −0.44; 95% CI = −0.085; −0.003). However, for women under treatment of AIs there was no relationship between physical activity and metabolic variables. Conclusion The amount of physical activity practice is inversely related to lipid profile, glucose and C-reactive protein in women without breast cancer. This relation was not observed in the cancer survivors, suggesting that the use of aromatase inhibitors could influence or low intensity of physical activity.en
dc.description.affiliationInstitute of Bioscience Department of Physical Education Sao Paulo State University (UNESP)
dc.description.affiliationCenter of Studies and Laboratory of Evaluation and Prescription of Motor Activities (CELAPAM) Department of Physical Education Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Physical Education Federal University of Amazonas (UFAM)
dc.description.affiliationGroup of Study in Physical Activity and Health Sao Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Bioscience Department of Physical Education Sao Paulo State University (UNESP)
dc.description.affiliationUnespCenter of Studies and Laboratory of Evaluation and Prescription of Motor Activities (CELAPAM) Department of Physical Education Sao Paulo State University (UNESP)
dc.description.affiliationUnespGroup of Study in Physical Activity and Health Sao Paulo State University (UNESP)
dc.format.extent33-37
dc.identifierhttp://dx.doi.org/10.1016/j.ejogrb.2017.07.003
dc.identifier.citationEuropean Journal of Obstetrics Gynecology and Reproductive Biology, v. 216, p. 33-37.
dc.identifier.doi10.1016/j.ejogrb.2017.07.003
dc.identifier.file2-s2.0-85022045345.pdf
dc.identifier.issn1872-7654
dc.identifier.issn0301-2115
dc.identifier.scopus2-s2.0-85022045345
dc.identifier.urihttp://hdl.handle.net/11449/169901
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Obstetrics Gynecology and Reproductive Biology
dc.relation.ispartofsjr0,828
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAromatase inhibitors
dc.subjectBreast cancer
dc.subjectMetabolic variables
dc.subjectPhysical activity
dc.subjectPostmenopausal women
dc.titleRelationship between physical activity practice and metabolic profile of postmenopausal women under treatment with aromatase inhibitors for breast canceren
dc.typeArtigo

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