Effect of mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental crotalus durissus (Squamata: Viperidae) envenomation in rats

Página do item simplificado
dc.contributor.authorFloriano, Rafael Stuani
dc.contributor.authorNogueira, Rosa Maria Barilli
dc.contributor.authorSakate, Michiko [UNESP]
dc.contributor.authorLaposy, Cecília Braga
dc.contributor.authorda Motta, Yudney Pereira [UNESP]
dc.contributor.authorSangiorgio, Fabíola [UNESP]
dc.contributor.authorDavid, Heloísa Costa
dc.contributor.authorNabas, João Marcelo
dc.contributor.institutionAnimal Science at University of Western São Paulo - UNOESTE
dc.contributor.institutionUniversity of Western São Paulo, UNOESTE
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUNOESTE
dc.contributor.institutionFAI
dc.date.accessioned2022-04-28T21:00:30Z
dc.date.available2022-04-28T21:00:30Z
dc.date.issued2009-12-01
dc.description.abstractCrotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: Temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents.en
dc.description.affiliationAnimal Science at University of Western São Paulo - UNOESTE, Presidente Prudente, SP
dc.description.affiliationDepartment of Small Animals Medical Clinic University of Western São Paulo, UNOESTE, Presidente Prudente, SP
dc.description.affiliationDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Husbandry São Paulo State University, UNESP, Botucatu, SP
dc.description.affiliationDepartment of Clinical Pathology UNOESTE, Presidente Prudente, SP
dc.description.affiliationDepartment of Pharmacology Adamantinenses Integrated Schools FAI, Adamantina, SP
dc.description.affiliationUnespDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Husbandry São Paulo State University, UNESP, Botucatu, SP
dc.format.extent929-937
dc.identifier.citationRevista de Biologia Tropical, v. 57, n. 4, p. 929-937, 2009.
dc.identifier.issn0034-7744
dc.identifier.scopus2-s2.0-77949902792
dc.identifier.urihttp://hdl.handle.net/11449/225805
dc.language.isoeng
dc.relation.ispartofRevista de Biologia Tropical
dc.sourceScopus
dc.subjectAntivenom
dc.subjectCrotalus durissus terrificus
dc.subjectMikania glomerata
dc.subjectRat
dc.subjectVenom
dc.titleEffect of mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental crotalus durissus (Squamata: Viperidae) envenomation in ratsen
dc.typeArtigo

Arquivos

Coleções

Artigos - Clínica Veterinária - FMVZ