Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3)
| dc.contributor.author | Melo Pereira, José Clayston [UNESP] | |
| dc.contributor.author | Souza, Maykon Lima | |
| dc.contributor.author | Franco, Douglas Wagner | |
| dc.contributor.institution | Universidade de São Paulo (USP) | |
| dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
| dc.date.accessioned | 2015-10-21T20:23:18Z | |
| dc.date.available | 2015-10-21T20:23:18Z | |
| dc.date.issued | 2015-02-01 | |
| dc.description.abstract | The reaction between the trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3) and L-cysteine (RS-) was studied over a pH range of 2.0-7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the solution. The first step of this reaction proceeded quickly [k(1) = (3.5 +/- 0.3)x10(3) M-1 s(-1), pH = 3.5, 25 degrees C] and resulted in the formation of trans-[Ru(NH3)(4)P(OEt)(3)N(O)SR](2+), which dissociated to yield trans-[Ru(NH3)(4)P(OEt)(3)NO](2+) and RS. However, trans-[Ru(NH3)(4)P(OEt)(3)N(O)SR](n-1) can react with a second L-cysteine, yielding trans-[Ru(NH3)(4)P(OEt)(3)N(O)(SR)(2)](+) [k(2) = (3.6 +/- 0.1) M(-1)s(-1), pH = 3.5, 25 degrees C]. Therefore, the trans-[Ru(NH3)(4)P(OEt)(3)NO](2+) species released NO and the trans-[Ru(NH3)(4)P(OEt)(3)N(O)(SR)(2)](n-2) species released HNO. | en |
| dc.description.affiliation | Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trabalhador São Carlense, CEP: 13560-970 – São Carlos – SP, Brazil | |
| dc.description.affiliationUnesp | Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP – Universidade Estadual Paulista, P. O. Box 355, Araraquara, São Paulo 14801-970, Brazil | |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.format.extent | 1005-1011 | |
| dc.identifier | http://onlinelibrary.wiley.com/doi/10.1002/ejic.201402992/full | |
| dc.identifier.citation | European Journal Of Inorganic Chemistry. Weinheim: Wiley-v C H Verlag Gmbh, v. 2015, n. 6, p. 1005-1011, 2015. | |
| dc.identifier.doi | 10.1002/ejic.201402992 | |
| dc.identifier.issn | 1434-1948 | |
| dc.identifier.uri | http://hdl.handle.net/11449/129112 | |
| dc.identifier.wos | WOS:000349976200013 | |
| dc.language.iso | eng | |
| dc.publisher | Wiley-Blackwell | |
| dc.relation.ispartof | European Journal Of Inorganic Chemistry | |
| dc.relation.ispartofjcr | 2.507 | |
| dc.relation.ispartofsjr | 0,828 | |
| dc.rights.accessRights | Acesso restrito | |
| dc.source | Web of Science | |
| dc.subject | Nitric oxide | en |
| dc.subject | Nitroxyl | en |
| dc.subject | Nitrogen oxides | en |
| dc.subject | Ruthenium | en |
| dc.subject | Kinetics | en |
| dc.subject | Medicinal chemistry | en |
| dc.title | Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3) | en |
| dc.type | Artigo | |
| dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
| dcterms.rightsHolder | Wiley-Blackwell | |
| unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Química, Araraquara | pt |
| unesp.department | Química Inorgânica - IQAR | pt |