Recent advances in the management of neuropsychiatric symptoms in dementia

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dc.contributor.authorForlenza, Orestes V.
dc.contributor.authorLoureiro, J�lia Cunha
dc.contributor.authorPais, Marcos Vasconcelos
dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.institutionInstituto de Psiquiatria - Hospital das Cl�nicas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:30:58Z
dc.date.available2018-12-11T17:30:58Z
dc.date.issued2017-01-01
dc.description.abstractPurpose of review The present article addresses intriguing questions related to the clinical intervention in distinct neuropsychiatric syndromes of patients with dementia. Recent findings We reviewed 154 articles published between 2015 and 2016 targeting psychopharmacological and nonpharmacological interventions, and safety-tolerability concerns. We selected 115 articles addressing the purpose of this study. Of these, 33 were chosen because they were dedicated to subtopics: agitation (42), depression (33), apathy (18), sleep disorders/anxiety (8), and psychosis (4). Clinical studies using both pharmacological (70) and nonpharmacological (37) interventions were considered; others were included for theoretical support. Regarding the methodological design, we found double-blind RCTs (17), single-blinded RCTs (4), open-label studies (18), case reports (5), cross-sectional or cohort studies (25), epidemiological papers (2), and expert reviews (44). This observation raises concerns about the overall methodological adequacy of a substantial proportion of studies in this field, which limits the potential of generalization of the findings. Finally, 18 studies were designed to determine safety-tolerability issues of psychotropic medications (6 were discussed). Summary Effective and well tolerated treatment of neuropsychiatric syndromes in dementia remains a critically unsolved challenge. We understand that this is an extremely important area of research, and critically required to guide clinical decisions in geriatric neuropsychiatry.en
dc.description.affiliationLaboratory of Neuroscience (LIM-27) Department and Institute of Psychiatry Faculty of Medicine University of S�o Paulo Instituto de Psiquiatria - Hospital das Cl�nicas, Rua Dr Ov�dio Pires de Campos 785-1st floor
dc.description.affiliationUNESP - Universidade Estadual Paulista Biosciences Institute, Campus of Rio Claro, SP
dc.description.affiliationUnespUNESP - Universidade Estadual Paulista Biosciences Institute, Campus of Rio Claro, SP
dc.format.extent151-158
dc.identifierhttp://dx.doi.org/10.1097/YCO.0000000000000309
dc.identifier.citationCurrent Opinion in Psychiatry, v. 30, n. 2, p. 151-158, 2017.
dc.identifier.doi10.1097/YCO.0000000000000309
dc.identifier.issn1473-6578
dc.identifier.issn0951-7367
dc.identifier.scopus2-s2.0-85009343264
dc.identifier.urihttp://hdl.handle.net/11449/178569
dc.language.isoeng
dc.relation.ispartofCurrent Opinion in Psychiatry
dc.relation.ispartofsjr1,745
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBehavioral and psychological symptoms of dementia
dc.subjectCognition
dc.subjectDementia
dc.subjectNeuropsychiatric symptoms
dc.subjectNonpharmacological interventions
dc.subjectPharmacological management
dc.titleRecent advances in the management of neuropsychiatric symptoms in dementiaen
dc.typeResenha

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