Bi-Anodal Transcranial Direct Current Stimulation Combined With Treadmill Walking Decreases Motor Cortical Activity in Young and Older Adults

dc.contributor.authorOrcioli-Silva, Diego [UNESP]
dc.contributor.authorIslam, Aisha
dc.contributor.authorBaker, Mark R.
dc.contributor.authorGobbi, Lilian Teresa Bucken [UNESP]
dc.contributor.authorRochester, Lynn
dc.contributor.authorPantall, Annette
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionNewcastle University
dc.date.accessioned2022-05-01T11:39:07Z
dc.date.available2022-05-01T11:39:07Z
dc.date.issued2021-12-03
dc.description.abstractBackground: Walking in the “real world” involves motor and cognitive processes. In relation to this, declines in both motor function and cognition contribute to age-related gait dysfunction. Transcranial direct current stimulation (tDCS) and treadmill walking (STW) have potential to improve gait, particularly during dual-task walking (DTW); walking whilst performing a cognitive task. Our aims were to analyze effects of combined anodal tDCS + STW intervention on cortical activity and gait during DTW. Methods: Twenty-three young adults (YA) and 21 older adults (OA) were randomly allocated to active or sham tDCS stimulation groups. Participants performed 5-min of mixed treadmill walking (alternating 30 s bouts of STW and DTW) before and after a 20-min intervention of active or sham tDCS + STW. Anodal electrodes were placed over the left prefrontal cortex (PFC) and the vertex (Cz) using 9 cm2 electrodes at 0.6 mA. Cortical activity of the PFC, primary motor cortex (M1), premotor cortex (PMC), and supplementary motor area (SMA) bilaterally were recorded using a functional near-infrared spectroscopy (fNIRS) system. Oxygenated hemoglobin (HbO2) levels were analyzed as indicators of cortical activity. An accelerometer measured gait parameters. We calculated the difference between DTW and STW for HbO2 and gait parameters. We applied linear mixed effects models which included age group (YA vs. OA), stimulation condition (sham vs. active), and time (pre- vs. post-intervention) as fixed effects. Treadmill belt speed was a covariate. Partial correlation tests were also performed. Results: A main effect of age group was observed. OA displayed higher activity bilaterally in the PFC and M1, unilaterally in the right PMC and higher gait variability than YA. M1 activity decreased in both YA and OA following active tDCS + STW. There was no overall effect of tDCS + STW on PFC activity or gait parameters. However, negative correlations were observed between changes in left PFC and stride length variability following active tDCS + STW intervention. Conclusion: Increased activity in multiple cortical areas during DTW in OA may act as a compensatory mechanism. Reduction in M1 activity following active tDCS + STW with no observed gait changes suggests improved neural efficiency.en
dc.description.affiliationInstitute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationGraduate Program in Movement Sciences São Paulo State University (UNESP)
dc.description.affiliationTranslational and Clinical Research Institute Newcastle University
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationUnespGraduate Program in Movement Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3389/fnagi.2021.739998
dc.identifier.citationFrontiers in Aging Neuroscience, v. 13.
dc.identifier.doi10.3389/fnagi.2021.739998
dc.identifier.issn1663-4365
dc.identifier.scopus2-s2.0-85121435608
dc.identifier.urihttp://hdl.handle.net/11449/233915
dc.language.isoeng
dc.relation.ispartofFrontiers in Aging Neuroscience
dc.sourceScopus
dc.subjectageing
dc.subjectcognition
dc.subjectfunctional near-infrared spectroscopy
dc.subjectlocomotion
dc.subjectnon-invasive brain stimulation
dc.titleBi-Anodal Transcranial Direct Current Stimulation Combined With Treadmill Walking Decreases Motor Cortical Activity in Young and Older Adultsen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.departmentEducação Física - IBpt

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