The acylpolyamines from spider venoms

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dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:31Z
dc.date.available2014-05-27T11:26:31Z
dc.date.issued2012-05-22
dc.description.abstractAcylpolyamines are low molecular mass toxins occurring exclusively in the venoms from solitary wasps and some groups of spiders. Their chemical structures have been elucidated using hyphenated techniques of mass spectrometry, such as LC-MS and MS/MS, or through direct analysis with different types of NMR analyses. The chemical structures of the acylpolyamine toxins from the venoms of Nephilinae orb-web spiders appear to be organized into four parts based on the combinatorial way that the chemical building blocks are bound to each other. An aromatic moiety (part I) is connected through a linker amino acid (part II) to a polyamine chain (part III), which in turn may be connected to an optional tail (part IV). The polyamine chains were classified into seven subtypes according to the different combinations of chemical building blocks. These polyamine chains, in turn, are connected to one of three chromophore moieties: a 2,4-dihydroxyphenyl acetyl group, a 4-hydroxyindolyl acetyl group, or an indolyl acetyl group. They may be connected through an asparagine residue or sometimes through the dipeptide ornithyl asparagine. Also, nine different types of backbone tails may be attached to the polyamine chains. These toxins are noncompetitive blockers of ionotropic glutamate receptors with neuroprotective action against the neuronal death and antiepileptic effect. Thus, compounds of this class of spider venom toxin seem to represent interesting molecular models for the development of novel neuropharmaceutical drugs. © 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationLaboratory of Structural Biology and Zoochemistry Institute of Biosciences São Paulo State University (UNESP), Rio Claro, São Paulo
dc.description.affiliationUnespLaboratory of Structural Biology and Zoochemistry Institute of Biosciences São Paulo State University (UNESP), Rio Claro, São Paulo
dc.format.extent27-42
dc.identifierhttp://dx.doi.org/10.1016/B978-0-444-53836-9.00019-0
dc.identifier.citationStudies in Natural Products Chemistry, v. 36, p. 27-42.
dc.identifier.doi10.1016/B978-0-444-53836-9.00019-0
dc.identifier.issn1572-5995
dc.identifier.lattes2901888624506535
dc.identifier.scopus2-s2.0-84861137029
dc.identifier.urihttp://hdl.handle.net/11449/73333
dc.language.isoeng
dc.relation.ispartofStudies in Natural Products Chemistry
dc.relation.ispartofsjr0,206
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectGlutamate receptors
dc.subjectNeuroblockers
dc.subjectOrb-web spiders
dc.subjectStructure determination
dc.subjectToxins
dc.titleThe acylpolyamines from spider venomsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes2901888624506535
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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