Different doses of exogenous surfactant for treatment of meconium aspiration syndrome in newborn rabbits.

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dc.contributor.authorLyra, João Cesar
dc.contributor.authorMascaretti, Renata S
dc.contributor.authorPrecioso, Alexander Roberto
dc.contributor.authorChang, Yin Chia
dc.contributor.authorCosta, Maria Tereza Zulini da
dc.contributor.authorVaz, Flávio Adolfo Costa
dc.contributor.authorOkay, Yassuhiko
dc.contributor.authorRebello, Celso Moura
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:05Z
dc.date.available2014-05-27T11:21:05Z
dc.date.issued2004-06-01
dc.description.abstractOBJECTIVE: To evaluate the effects of 2 different doses of exogenous surfactant on pulmonary mechanics and on the regularity of pulmonary parenchyma inflation in newborn rabbits. METHOD: Newborn rabbits were submitted to tracheostomy and randomized into 4 study groups: the Control group did not receive any material inside the trachea; the MEC group was instilled with meconium, without surfactant treatment; the S100 and S200 groups were instilled with meconium and were treated with 100 and 200 mg/kg of exogenous surfactant (produced by Instituto Butantan) respectively. Animals from the 4 groups were mechanically ventilated during a 25-minute period. Dynamic compliance, ventilatory pressure, tidal volume, and maximum lung volume (P-V curve) were evaluated. Histological analysis was conducted using the mean linear intercept (Lm), and the lung tissue distortion index (SDI) was derived from the standard deviation of the means of the Lm. One-way analysis of variance was used with a = 0.05. RESULTS: After 25 minutes of ventilation, dynamic compliance (mL/cm H2O.kg) was 0.87 +/- 0.07 (Control); 0.49 +/- 0.04 (MEC*); 0.67 +/- 0.06 (S100); and 0.67 +/- 0.08 (S200), and ventilatory pressure (cm H2O) was 9.0 +/- 0.9 (Control); 16.5 +/- 1.7 (MEC*); 12.4 +/- 1.1 (S100); and 12.1 +/- 1.5 (S200). Both treated groups had lower Lm values and more homogeneity in the lung parenchyma compared to the MEC group: SDI = 7.5 +/- 1.9 (Control); 11.3 +/- 2.5 (MEC*), 5.8 +/- 1.9 (S100); and 6.7 +/- 1.7 (S200) (*P < 0.05 versus all the other groups). CONCLUSIONS: Animals treated with surfactant showed significant improvement in pulmonary mechanics and more regularity of the lung parenchyma in comparison to untreated animals. There was no difference in results after treatment with either of the doses used.en
dc.format.extent104-112
dc.identifierhttp://dx.doi.org/10.1590/S0041-87812004000300003
dc.identifier.citationRevista do Hospital das Clinicas, v. 59, n. 3, p. 104-112, 2004.
dc.identifier.doi10.1590/S0041-87812004000300003
dc.identifier.file2-s2.0-28744456067.pdf
dc.identifier.issn0041-8781
dc.identifier.scieloS0041-87812004000300003
dc.identifier.scopus2-s2.0-28744456067
dc.identifier.urihttp://hdl.handle.net/11449/67749
dc.language.isoeng
dc.relation.ispartofRevista do Hospital das Clínicas
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectlung surfactant
dc.subjectanimal
dc.subjectartificial ventilation
dc.subjectbreathing mechanics
dc.subjectcomparative study
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthuman
dc.subjectlung compliance
dc.subjectlung gas exchange
dc.subjectmale
dc.subjectmeconium aspiration
dc.subjectnewborn
dc.subjectrabbit
dc.subjecttime
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectLung Compliance
dc.subjectMale
dc.subjectMeconium Aspiration Syndrome
dc.subjectPulmonary Gas Exchange
dc.subjectPulmonary Surfactants
dc.subjectRabbits
dc.subjectRespiration, Artificial
dc.subjectRespiratory Mechanics
dc.subjectTime Factors
dc.titleDifferent doses of exogenous surfactant for treatment of meconium aspiration syndrome in newborn rabbits.en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rhc/paboutj.htm

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