Consolidation chemotherapy in postmolar low-risk gestational trophoblastic neoplasia: a systematic review protocol

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dc.contributor.authorBranco-Silva, Mariza [UNESP]
dc.contributor.authorMaesta, Izildinha [UNESP]
dc.contributor.authorElias, Kevin
dc.contributor.authorBerkowitz, Ross Stuart
dc.contributor.authorAbbade, Joelcio Francisco [UNESP]
dc.contributor.authorHorowitz, Neil S.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionHarvard Medical School
dc.date.accessioned2022-04-29T08:40:04Z
dc.date.available2022-04-29T08:40:04Z
dc.date.issued2022-02-24
dc.description.abstractINTRODUCTION: Current evidence remains insufficient to strongly demonstrate the benefits of consolidation chemotherapy to all women with low-risk gestational trophoblastic neoplasia (GTN). This protocol outlines a systematic review to investigate whether consolidation chemotherapy is necessary for all patients with postmolar low-risk GTN after human chorionic gonadotropin normalisation with first-line single-agent chemotherapy. METHODS AND ANALYSIS: A search string will be used to search the PubMed (MEDLINE), EMBASE, Web of Sciences, Scopus, LILACS and Cochrane Central Register of Controlled Trials databases. Articles will be screened at the title and abstract level, and then at the full article level by two independent reviewers using inclusion/exclusion criteria. Randomised and non-randomised study designs will be included, while case studies, commentaries, editorials, review articles, animal studies, basic science studies and cross-sectional studies, as well as studies not reporting relapse/recurrence rates and/or whether consolidation chemotherapy was delivered will be excluded. There will be no restrictions on date of publication, geographical location, study setting, or language of publication. The primary outcome is rate of recurrence/relapse. The assessments of randomised controlled trials will be performed using the risk of bias tool from the Cochrane Collaboration. Non-randomised studies will be assessed using the Newcastle-Ottawa scale. The quality of evidence will be assessed using the Grading quality of evidence and strength of recommendations (Grades of Recommendations, Assessment, Development and Evaluation) guidelines. ETHICS AND DISSEMINATION: No formal ethical approval is required as all data collected will be secondary data and analysed anonymously. Results will be disseminated through a peer-reviewed publication and at scientific events. PROSPERO REGISTRATION NUMBER: CRD42020164822.en
dc.description.affiliationBotucatu Medical School Postgraduation Program in Tocogynecology Sao Paulo State University Julio de Mesquita Filho
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University Julio de Mesquita Filho
dc.description.affiliationBotucatu Trophoblastic Disease Center Botucatu Medical School Hospital São Paulo State University Julio de Mesquita Filho - UNESP
dc.description.affiliationDepartment of Obstetrics Gynecology and Reproductive Biology Harvard Medical School
dc.description.affiliationUnespBotucatu Medical School Postgraduation Program in Tocogynecology Sao Paulo State University Julio de Mesquita Filho
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University Julio de Mesquita Filho
dc.description.affiliationUnespBotucatu Trophoblastic Disease Center Botucatu Medical School Hospital São Paulo State University Julio de Mesquita Filho - UNESP
dc.format.extente059484
dc.identifierhttp://dx.doi.org/10.1136/bmjopen-2021-059484
dc.identifier.citationBMJ open, v. 12, n. 2, p. e059484-, 2022.
dc.identifier.doi10.1136/bmjopen-2021-059484
dc.identifier.issn2044-6055
dc.identifier.scopus2-s2.0-85125306946
dc.identifier.urihttp://hdl.handle.net/11449/230460
dc.language.isoeng
dc.relation.ispartofBMJ open
dc.sourceScopus
dc.subjectchemotherapy
dc.subjectgynaecological oncology
dc.titleConsolidation chemotherapy in postmolar low-risk gestational trophoblastic neoplasia: a systematic review protocolen
dc.typeArtigo
unesp.author.orcid0000-0001-8145-2962[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentGinecologia e Obstetrícia - FMBpt

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Botucatu - FMB - Faculdade de Medicina