Experimental Measurements of the {CO2 (1) + Acetone (2) + Ivermectin (3)} System at High Pressure

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dc.contributor.authorJunior, Osvaldo Valarini
dc.contributor.authorFerreira-Pinto, Leandro [UNESP]
dc.contributor.authorCabral, Vladimir Ferreira
dc.contributor.authorGiufrida, Willyan Machado
dc.contributor.authorCardozo-Filho, Lúcio
dc.contributor.institutionState University of Maringá
dc.contributor.institutionFaculdade de Engenharias e Arquitetura (FEITEP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCentro Universitario da Fundação de Ensino Octavio Bastos (UNIFEOB)
dc.date.accessioned2019-10-06T15:55:30Z
dc.date.available2019-10-06T15:55:30Z
dc.date.issued2019-01-01
dc.description.abstractFor potential application to the controlled release of ivermectin from nanoparticle preparations, this study discloses experimental data on the phase transitions in the CO2, acetone, and ivermectin system subjected to high pressures. The data were acquired via the static synthetic method with a variable-volume view cell in the temperature range of 303.15-333.15 K at pressures up to 10 MPa using three concentrations of ivermectin B1a in acetone (0.029, 0.043, and 0.058 mol·kg-1) and CO2 molar fractions of 0.3-0.9. Vapor-liquid-type phase transitions were observed, characterized as bubbles in the presence or absence of a solid phase. A solid phase was formed for all ivermectin B1a concentrations evaluated in this study. Determination of the region of precipitation of ivermectin is important for identifying the concentration of the acetone/ivermectin mixture where CO2 will act strongly as an antisolvent. Thermodynamic modeling was performed by considering the system as pseudo-ternary based on the low concentration of ivermectin B1a in the system. Thermodynamics modeling using the Peng-Robinson cubic state equation with the van der Waals mixing rule (PR-vdW2) adequately described the experimentally observed trends.en
dc.description.affiliationDepartment of Chemical Engineering State University of Maringá
dc.description.affiliationFaculdade de Engenharias e Arquitetura (FEITEP)
dc.description.affiliationDepartment of Energy Engineering Sao Paulo State University (UNESP)
dc.description.affiliationResearch Center Centro Universitario da Fundação de Ensino Octavio Bastos (UNIFEOB)
dc.description.affiliationUnespDepartment of Energy Engineering Sao Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1021/acs.jced.9b00072
dc.identifier.citationJournal of Chemical and Engineering Data.
dc.identifier.doi10.1021/acs.jced.9b00072
dc.identifier.issn1520-5134
dc.identifier.issn0021-9568
dc.identifier.scopus2-s2.0-85071729734
dc.identifier.urihttp://hdl.handle.net/11449/188042
dc.language.isoeng
dc.relation.ispartofJournal of Chemical and Engineering Data
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.titleExperimental Measurements of the {CO2 (1) + Acetone (2) + Ivermectin (3)} System at High Pressureen
dc.typeArtigo
unesp.author.orcid0000-0002-0656-9471[5]

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