Bilateral canine seminoma with ocular metastasis: Histochemical and immunohistochemical characterization

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dc.contributor.authorRivera-Calderón, Luis Gabriel
dc.contributor.authorMontoya-Flórez, Luis Mauricio
dc.contributor.authorSilva, Germana A. [UNESP]
dc.contributor.authorSanctis, Paula [UNESP]
dc.contributor.authorBelluci, Renata S. [UNESP]
dc.contributor.authorBrandao, Claudia Valeria [UNESP]
dc.contributor.authorRocha, Noeme S. [UNESP]
dc.contributor.institutionUniversidad Antonio Nariño (UAN)
dc.contributor.institutionUniversidad de Caldas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGIDIMEVETZ Universidad Pedagógica y Tecnológica de Colombia
dc.date.accessioned2020-12-12T02:22:30Z
dc.date.available2020-12-12T02:22:30Z
dc.date.issued2020-03-01
dc.description.abstractA 10-year old male dog was examined due to a buphthalmia in the left eye and a nodule in the two testicles. Due to the limited resources of the owner and loss of visual acuity of the patient, the enucleation and castration were chosen as treatment. Microscopic analysis of the testicular tissue revealed neoplastic germ cells. Morphologically, neoplastic cells were characterized by distinct cell borders, scarce and eosinophilic cytoplasm, large round nucleus, with thick chromatin and a prominent nucleolus. Binucleated and multinucleated neoplastic cells were also frequently observed. In 10 high power fields (400x), 62 typical and atypical mitosis were counted. Similar neoplastic cells were identified within the vessels of the retina, sclera and in the sub-epithelial conjunctive tissue of the eyelid. The neoplastic cells observed in the testicle and in the eye were positive for PAS. By immunochemistry technique was identified an intense immunostaining of the neoplastic cells for Vimentin and Ki-67 in both testicular and ocular tissue. While, discrete immunoreactivity was identified to c-KIT from the neoplastic cells in both organs. Based on morphological, histochemical and immunohistochemical analysis, it was possible to characterize the ocular lesion as seminoma metastasis.en
dc.description.affiliationCollege of Veterinary Medicine and Animal Husbandry Universidad Antonio Nariño (UAN)
dc.description.affiliationFaculty of Veterinary Medicine Universidad Nacional de Colombia Veterinary Pathology Research Group Universidad de Caldas
dc.description.affiliationDepartment of Veterinary Clinic and Surgery College of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)
dc.description.affiliationPathology College of Medicine from Botucatu São Paulo State University
dc.description.affiliationDepartment of Veterinary Clinic College of Veterinary Medicine and Animal Husbandry São Paulo State University
dc.description.affiliationGIDIMEVETZ Universidad Pedagógica y Tecnológica de Colombia
dc.description.affiliationUnespDepartment of Veterinary Clinic and Surgery College of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespPathology College of Medicine from Botucatu São Paulo State University
dc.description.affiliationUnespDepartment of Veterinary Clinic College of Veterinary Medicine and Animal Husbandry São Paulo State University
dc.format.extent57-61
dc.identifierhttp://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p57-61
dc.identifier.citationBrazilian Journal of Veterinary Pathology, v. 13, n. 1, p. 57-61, 2020.
dc.identifier.doi10.24070/bjvp.1983-0246.v13i1p57-61
dc.identifier.issn1983-0246
dc.identifier.lattes1087615389013655
dc.identifier.orcid0000-0002-2011-5214
dc.identifier.scopus2-s2.0-85090607400
dc.identifier.urihttp://hdl.handle.net/11449/201038
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Veterinary Pathology
dc.sourceScopus
dc.subjectC-KIT
dc.subjectDog
dc.subjectImmunohistochemistry
dc.subjectInhibin-α
dc.subjectKi-67
dc.subjectNeoplasia
dc.titleBilateral canine seminoma with ocular metastasis: Histochemical and immunohistochemical characterizationen
dc.typeArtigo
unesp.author.lattes1087615389013655[6]
unesp.author.orcid0000-0002-2011-5214[6]

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Artigos - Patologia - FMB
Artigos - Clínica Veterinária - FMVZ