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Isolation and chemical characterization of PwTx-II: A novel alkaloid toxin from the venom of the spider Parawixia bistriata (Araneidae, Araneae)

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dc.contributor.authorCesar, LMM
dc.contributor.authorMendes, M. A.
dc.contributor.authorTormena, C. F.
dc.contributor.authorMarques, M. R.
dc.contributor.authorde Souza, B. M.
dc.contributor.authorSaidemberg, D. M.
dc.contributor.authorBittencourt, J. C.
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:28:29Z
dc.date.available2014-05-20T15:28:29Z
dc.date.issued2005-12-01
dc.description.abstractBrazil has many species of spiders belonging to Araneidae family however, very little is known about the composition, chemical structure and mechanisms of action of the main venom components of these spiders. The main objective of this work was to isolate and to perform the chemical characterization of a novel beta-carboline toxin from the venom of the spider Parawixia bistriata, a typical species of the Brazilian 'cerrado'. The toxin was purified by RP-HPLC and structurally elucidated by using a combination of different spectroscopic techniques (UV, ESI-MS/MS and H-1 NMR), which permitted the assignment of the molecular structure of a novel spider venom toxin, identified as 1-4-guanidinobutoxy-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline, and referred to here as PwTx-II. This compound is toxic to insects (LD50 = 12 +/- 3 eta g/mg honeybee), neurotoxic, convulsive and lethal to rats (LD50 = 9.75 mg/kg of male Wistar rat). (c) 2005 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Filosofia Ciências & Letras Ribeirao Pret, Dept Chem, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Anat, Lab Chem Neuroanat, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biosci, BR-13506900 Rio Claro, SP, Brazil
dc.format.extent786-796
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2005.08.005
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 46, n. 7, p. 786-796, 2005.
dc.identifier.doi10.1016/j.toxicon.2005.08.005
dc.identifier.issn0041-0101
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/38291
dc.identifier.wosWOS:000233491400010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectspider venompt
dc.subjectspider toxinpt
dc.subjectnatural compoundpt
dc.subjectalkaloidpt
dc.subjectstructure determinationpt
dc.subjectneurotoxicitypt
dc.subjectnatural productpt
dc.subjectspectroscopypt
dc.titleIsolation and chemical characterization of PwTx-II: A novel alkaloid toxin from the venom of the spider Parawixia bistriata (Araneidae, Araneae)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0002-2078-9286[2]
unesp.author.orcid0000-0002-8908-6474[7]
unesp.author.orcid0000-0002-7363-8211[8]
unesp.author.orcid0000-0002-1508-0694[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.departmentBiologia - IBpt

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Rio Claro - IB - Instituto de Biociências