p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease

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dc.contributor.authorBellini, Marilanda Ferreira [UNESP]
dc.contributor.authorLeite, Kátia Ramos Moreira
dc.contributor.authorCury, Patrícia Maluf
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionHospital Sírio Libanês
dc.contributor.institutionFAMERP - Medical School
dc.date.accessioned2022-04-28T20:48:14Z
dc.date.available2022-04-28T20:48:14Z
dc.date.issued2008-11-01
dc.description.abstractBackground: Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma. While numerous genetic alterations have been reported in esophageal carcinogenesis, studies of benign lesions with precancerous potential are scarce. Materials and Methods: Immunohistochemistry was performed for p53, p16 and Fhit proteins in the esophageal mucosa from patients with Chagas disease (CD), chagasic megaesophagus (CM), chronic esophagitis (CE), esophageal squamous cell carcinoma (ESCC) and in normal mucosa (NM). Results: The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (52.2%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. Conclusion: p53 overexpression is involved in the initial steps of esophageal carcinogenesis, supporting further evaluation of its utility as a marker in precursor lesions, conversely, losses of Fhit and p16 expression may not be significant.en
dc.description.affiliationDepartment of Biology UNESP Säo Paulo State University, SP
dc.description.affiliationLaboratory of Surgery and Molecular Pathology Hospital Sírio Libanês, São Paulo, SP
dc.description.affiliationDepartment of Pathology FAMERP - Medical School, São José do Rio Preto, SP
dc.description.affiliationIBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000
dc.description.affiliationUnespDepartment of Biology UNESP Säo Paulo State University, SP
dc.description.affiliationUnespIBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000
dc.format.extent3793-3799
dc.identifier.citationAnticancer Research, v. 28, n. 6 A, p. 3793-3799, 2008.
dc.identifier.issn0250-7005
dc.identifier.scopus2-s2.0-58149174373
dc.identifier.urihttp://hdl.handle.net/11449/225387
dc.language.isoeng
dc.relation.ispartofAnticancer Research
dc.sourceScopus
dc.subjectEsophageal carcinoma
dc.subjectEsophagitis
dc.subjectFhit protein
dc.subjectMegaesophagus
dc.subjectp16
dc.subjectp53
dc.titlep53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas diseaseen
dc.typeArtigo

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