p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease
dc.contributor.author | Bellini, Marilanda Ferreira [UNESP] | |
dc.contributor.author | Leite, Kátia Ramos Moreira | |
dc.contributor.author | Cury, Patrícia Maluf | |
dc.contributor.author | Silva, Ana Elizabete [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Hospital Sírio Libanês | |
dc.contributor.institution | FAMERP - Medical School | |
dc.date.accessioned | 2022-04-28T20:48:14Z | |
dc.date.available | 2022-04-28T20:48:14Z | |
dc.date.issued | 2008-11-01 | |
dc.description.abstract | Background: Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma. While numerous genetic alterations have been reported in esophageal carcinogenesis, studies of benign lesions with precancerous potential are scarce. Materials and Methods: Immunohistochemistry was performed for p53, p16 and Fhit proteins in the esophageal mucosa from patients with Chagas disease (CD), chagasic megaesophagus (CM), chronic esophagitis (CE), esophageal squamous cell carcinoma (ESCC) and in normal mucosa (NM). Results: The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (52.2%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. Conclusion: p53 overexpression is involved in the initial steps of esophageal carcinogenesis, supporting further evaluation of its utility as a marker in precursor lesions, conversely, losses of Fhit and p16 expression may not be significant. | en |
dc.description.affiliation | Department of Biology UNESP Säo Paulo State University, SP | |
dc.description.affiliation | Laboratory of Surgery and Molecular Pathology Hospital Sírio Libanês, São Paulo, SP | |
dc.description.affiliation | Department of Pathology FAMERP - Medical School, São José do Rio Preto, SP | |
dc.description.affiliation | IBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000 | |
dc.description.affiliationUnesp | Department of Biology UNESP Säo Paulo State University, SP | |
dc.description.affiliationUnesp | IBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000 | |
dc.format.extent | 3793-3799 | |
dc.identifier.citation | Anticancer Research, v. 28, n. 6 A, p. 3793-3799, 2008. | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.scopus | 2-s2.0-58149174373 | |
dc.identifier.uri | http://hdl.handle.net/11449/225387 | |
dc.language.iso | eng | |
dc.relation.ispartof | Anticancer Research | |
dc.source | Scopus | |
dc.subject | Esophageal carcinoma | |
dc.subject | Esophagitis | |
dc.subject | Fhit protein | |
dc.subject | Megaesophagus | |
dc.subject | p16 | |
dc.subject | p53 | |
dc.title | p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease | en |
dc.type | Artigo |