Screening of coformers for quercetin cocrystals through mechanochemical methods

Página do item simplificado
dc.contributor.authorDe Souza, Fayene Zeferino Ribeiro [UNESP]
dc.contributor.authorDe Almeida, Amanda Cosmo [UNESP]
dc.contributor.authorFerreira, Patrícia Osorio [UNESP]
dc.contributor.authorFernandes, Richard Perosa [UNESP]
dc.contributor.authorCaires, Flávio Junior [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:50:00Z
dc.date.available2022-04-28T19:50:00Z
dc.date.issued2022-01-01
dc.description.abstractQuercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility - among other properties - of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different.en
dc.description.affiliationSão Paulo State University School of Science
dc.description.affiliationSão Paulo State University Institute of Chemistry
dc.description.affiliationUnespSão Paulo State University School of Science
dc.description.affiliationUnespSão Paulo State University Institute of Chemistry
dc.format.extent64-75
dc.identifierhttp://dx.doi.org/10.26850/1678-4618eqj.v47.1.2022.p64-75
dc.identifier.citationEcletica Quimica, v. 47, n. 1, p. 64-75, 2022.
dc.identifier.doi10.26850/1678-4618eqj.v47.1.2022.p64-75
dc.identifier.issn1678-4618
dc.identifier.issn0100-4670
dc.identifier.scopus2-s2.0-85123410556
dc.identifier.urihttp://hdl.handle.net/11449/223320
dc.language.isoeng
dc.relation.ispartofEcletica Quimica
dc.sourceScopus
dc.subjectCocrystallization
dc.subjectFlavonoid
dc.subjectMechanochemistry
dc.subjectNutraceutical
dc.subjectThermal analysis
dc.titleScreening of coformers for quercetin cocrystals through mechanochemical methodsen
dc.typeArtigo

Arquivos

Coleções

Artigos