Screening of coformers for quercetin cocrystals through mechanochemical methods
dc.contributor.author | De Souza, Fayene Zeferino Ribeiro [UNESP] | |
dc.contributor.author | De Almeida, Amanda Cosmo [UNESP] | |
dc.contributor.author | Ferreira, Patrícia Osorio [UNESP] | |
dc.contributor.author | Fernandes, Richard Perosa [UNESP] | |
dc.contributor.author | Caires, Flávio Junior [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-28T19:50:00Z | |
dc.date.available | 2022-04-28T19:50:00Z | |
dc.date.issued | 2022-01-01 | |
dc.description.abstract | Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility - among other properties - of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different. | en |
dc.description.affiliation | São Paulo State University School of Science | |
dc.description.affiliation | São Paulo State University Institute of Chemistry | |
dc.description.affiliationUnesp | São Paulo State University School of Science | |
dc.description.affiliationUnesp | São Paulo State University Institute of Chemistry | |
dc.format.extent | 64-75 | |
dc.identifier | http://dx.doi.org/10.26850/1678-4618eqj.v47.1.2022.p64-75 | |
dc.identifier.citation | Ecletica Quimica, v. 47, n. 1, p. 64-75, 2022. | |
dc.identifier.doi | 10.26850/1678-4618eqj.v47.1.2022.p64-75 | |
dc.identifier.issn | 1678-4618 | |
dc.identifier.issn | 0100-4670 | |
dc.identifier.scopus | 2-s2.0-85123410556 | |
dc.identifier.uri | http://hdl.handle.net/11449/223320 | |
dc.language.iso | eng | |
dc.relation.ispartof | Ecletica Quimica | |
dc.source | Scopus | |
dc.subject | Cocrystallization | |
dc.subject | Flavonoid | |
dc.subject | Mechanochemistry | |
dc.subject | Nutraceutical | |
dc.subject | Thermal analysis | |
dc.title | Screening of coformers for quercetin cocrystals through mechanochemical methods | en |
dc.type | Artigo |