Hepatoencephalopathy syndrome due to Cassia occidentalis (Leguminosae, Caesalpinioideae) seed ingestion in horses

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dc.contributor.authorOliveira-Filho, J. P. [UNESP]
dc.contributor.authorCagnini, D. Q. [UNESP]
dc.contributor.authorBadial, P. R. [UNESP]
dc.contributor.authorPessoa, M. A.
dc.contributor.authorDel Piero, F.
dc.contributor.authorBorges, Alexandre Secorun [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMP Reprodução Equina Ltda
dc.contributor.institutionLouisiana State University
dc.date.accessioned2014-05-27T11:28:36Z
dc.date.available2014-05-27T11:28:36Z
dc.date.issued2013-03-01
dc.description.abstractCassia occidentalis is a bush from the Leguminosae family, subfamily Caesalpinoideae, and is a toxic plant of veterinary interest due to the occasional contamination of animal rations. This report describes the clinical and histopathological findings of an outbreak of C.occidentalis poisoning in horses. Twenty mares were poisoned after consuming ground corn contaminated with 8% of C.occidentalis seeds. Of the 20 animals affected, 12 died: 8 mares were found dead, 2 died 6h after the onset of clinical signs compatible with hepatic encephalopathy and the 2 other animals were subjected to euthanasia 12h after the onset of the clinical signs. The remaining 8 mares presented with mild depression and decreased appetite, but improved with treatment and no clinical sequelae were observed. In 6 animals that underwent a necropsy, an enhanced hepatic lobular pattern was noted and within the large intestine, a large number of seeds were consistently observed. Hepatocellular pericentrolobular necrosis and cerebral oedema were the main histological findings. In one mare, there was mild multifocal semimembranosus rhabdomyocytic necrosis and haemorrhage. Seeds collected from intestinal contents and sifted from the culpable feedstuff were planted. Examination of the leaves, flowers, fruits and seeds of the resultant plants identified C.occidentalis. Horses poisoned by C.occidentalis seeds demonstrate clinical signs associated with hepatoencephalopathy and frequently die suddenly. Lesions primarily involve the liver and secondarily, the central nervous system. Cassia occidentalis poisoning should be considered a differential diagnosis in horses with hepatoencephalopathy and special caution should be taken with horse rations to avoid contamination with seeds of this toxic plant. © 2012 EVJ Ltd.en
dc.description.affiliationDepartment of Veterinary Clinical Science College of Veterinary Medicine and Animal Science Univ Estadual Paulista (UNESP), Botucatu, Sao Paulo
dc.description.affiliationMP Reprodução Equina Ltda, Bauru, Sao Paulo
dc.description.affiliationDepartment of Pathobiological Sciences School of Veterinary Medicine Louisiana State University, Baton Rouge, LA
dc.description.affiliationUnespDepartment of Veterinary Clinical Science College of Veterinary Medicine and Animal Science Univ Estadual Paulista (UNESP), Botucatu, Sao Paulo
dc.format.extent240-244
dc.identifierhttp://dx.doi.org/10.1111/j.2042-3306.2012.00599.x
dc.identifier.citationEquine Veterinary Journal, v. 45, n. 2, p. 240-244, 2013.
dc.identifier.doi10.1111/j.2042-3306.2012.00599.x
dc.identifier.issn0425-1644
dc.identifier.issn2042-3306
dc.identifier.lattes9643433706163946
dc.identifier.scopus2-s2.0-84873107579
dc.identifier.urihttp://hdl.handle.net/11449/74726
dc.identifier.wosWOS:000314470000022
dc.language.isoeng
dc.relation.ispartofEquine Veterinary Journal
dc.relation.ispartofjcr2.022
dc.relation.ispartofsjr0,991
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCassia occidentalis
dc.subjectHepatoencephalopathy
dc.subjectHorse
dc.subjectPoisoning
dc.subjectplant toxin
dc.subjectanimal
dc.subjectanimal disease
dc.subjectanimal food
dc.subjectchemically induced disorder
dc.subjectchemistry
dc.subjectepidemic
dc.subjectfemale
dc.subjectfood contamination
dc.subjecthepatic encephalopathy
dc.subjecthorse
dc.subjecthorse disease
dc.subjectmaize
dc.subjectplant
dc.subjectplant seed
dc.subjectSenna
dc.subjectAnimal Feed
dc.subjectAnimals
dc.subjectDisease Outbreaks
dc.subjectFemale
dc.subjectFood Contamination
dc.subjectHepatic Encephalopathy
dc.subjectHorse Diseases
dc.subjectHorses
dc.subjectPlant Poisoning
dc.subjectPlants, Toxic
dc.subjectSeeds
dc.subjectSenna Plant
dc.subjectZea mays
dc.subjectAnimalia
dc.subjectCaesalpinioideae
dc.subjectEquidae
dc.subjectFabaceae
dc.subjectSenna occidentalis
dc.titleHepatoencephalopathy syndrome due to Cassia occidentalis (Leguminosae, Caesalpinioideae) seed ingestion in horsesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes9643433706163946[6]
unesp.author.orcid0000-0001-9890-2640[1]
unesp.author.orcid0000-0002-3988-3707[2]
unesp.author.orcid0000-0001-6256-8089[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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