Polymeric micelles-mediated photodynamic therapy

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dc.contributor.authorde Santana, Willian Max O.S. [UNESP]
dc.contributor.authorPochapski, Daniel José [UNESP]
dc.contributor.authorPulcinelli, Sandra H. [UNESP]
dc.contributor.authorFontana, Carla Raquel [UNESP]
dc.contributor.authorSantilli, Celso V. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:08:39Z
dc.date.available2023-07-29T16:08:39Z
dc.date.issued2023-01-01
dc.description.abstractPolymeric micelles (PM) have been demonstrating high potential as multifunctional therapeutic nanoplatforms for anticancer photodynamic therapy (PDT). PM increase photosensitizer (PS) accumulation in tumor tissues, thus improving its antitumor effect. The development of PM responsive to endogenous (e.g., pH, reducing agents, and hypoxia) or exogenous (e.g., light) stimuli makes these polymeric structures even more versatile, since the delivery of PS to the target tissue occurs with good spatio-temporal control. This chapter covers the application of PM in PDT, focusing on targeting and stimulus-responsiveness release strategies. Our discussion will be based on the physical-chemical properties of the PM and the interaction of these carriers with biological systems.en
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP), SP
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP), SP
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SP
dc.format.extent105-139
dc.identifierhttp://dx.doi.org/10.1016/B978-0-323-85595-2.00003-7
dc.identifier.citationNanomaterials for Photodynamic Therapy, p. 105-139.
dc.identifier.doi10.1016/B978-0-323-85595-2.00003-7
dc.identifier.scopus2-s2.0-85150125570
dc.identifier.urihttp://hdl.handle.net/11449/249767
dc.language.isoeng
dc.relation.ispartofNanomaterials for Photodynamic Therapy
dc.sourceScopus
dc.subjectcancer therapy
dc.subjectnanocarriers
dc.subjectorganic nanoparticles
dc.subjectPhotodynamic therapy
dc.subjectpolymeric micelles
dc.subjectpolymeric nanoparticles
dc.subjectstimuli-responsive nanoparticles
dc.titlePolymeric micelles-mediated photodynamic therapyen
dc.typeCapítulo de livro

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