Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs

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dc.contributor.authorPaulo, Rodrigo Rodrigues [UNESP]
dc.contributor.authorGalvão, Victoria Elizabeth [UNESP]
dc.contributor.authorda Silva, Gustavo Gomes [UNESP]
dc.contributor.authorPorto, Laura Pereira [UNESP]
dc.contributor.authorTonossu, Juliana Mayumi [UNESP]
dc.contributor.authorGandolfi, Maira Beatriz [UNESP]
dc.contributor.authorGuimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
dc.contributor.authorTakahira, Regina Kiomi [UNESP]
dc.contributor.authorRahal, Sheila Canevese [UNESP]
dc.contributor.authorMelchert, Alessandra [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:34:21Z
dc.date.available2023-07-29T13:34:21Z
dc.date.issued2023-06-01
dc.description.abstractThe study aimed to assess plasma Myeloperoxidase enzyme (MPO) and Ferric-reducing antioxidant power (FRAP) in obese dogs and compare them with ideal body weight dogs. Thirty-two dogs were distributed into two groups according to a 9-point body condition score (BCS), as follows: Control group (n = 16), dogs with a BCS of 4 or 5; Obese group (n = 16), dogs with a BCS of 8 or 9. Plasma MPO and FRAP assays, neutrophil count, lipid profile (cholesterol and triglycerides), and systolic blood pressure (SBP) were evaluated in both groups. The duration of obesity was defined based on history. The obese group showed higher values for body weight, BCS, SBP, neutrophil count, triglycerides, and MPO than the Control group. A positive correlation was observed between MPO concentrations and BCS and body weight. FRAP concentrations showed a positive correlation with the duration of obesity. The results suggested that an inflammatory state caused by obesity may promote increased neutrophil count and MPO concentrations, besides the positive correlation between MPO with BCS and body weight. The obesity in dogs promoted slight active MPO elevation, influenced by body weight, BCS, and neutrophil count. The FRAP assay did not show the expected reduction and, therefore, needs further investigation.en
dc.description.affiliationDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University - UNESP, São Paulo
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences São Paulo State University - UNESP, São Paulo
dc.description.affiliationDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University - UNESP, São Paulo
dc.description.affiliationUnespDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science São Paulo State University - UNESP, São Paulo
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences São Paulo State University - UNESP, São Paulo
dc.description.affiliationUnespDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University - UNESP, São Paulo
dc.format.extent1007-1013
dc.identifierhttp://dx.doi.org/10.1007/s11259-022-10059-w
dc.identifier.citationVeterinary Research Communications, v. 47, n. 2, p. 1007-1013, 2023.
dc.identifier.doi10.1007/s11259-022-10059-w
dc.identifier.issn1573-7446
dc.identifier.issn0165-7380
dc.identifier.scopus2-s2.0-85144872151
dc.identifier.urihttp://hdl.handle.net/11449/248096
dc.language.isoeng
dc.relation.ispartofVeterinary Research Communications
dc.sourceScopus
dc.subjectBody condition score
dc.subjectDogs
dc.subjectFerric-reducing antioxidant power
dc.subjectMyeloperoxidase enzyme
dc.subjectObesity
dc.titleMyeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogsen
dc.typeArtigo
unesp.author.orcid0000-0001-6329-5182[2]
unesp.author.orcid0000-0003-1848-6021[6]
unesp.author.orcid0000-0003-1944-2426[7]
unesp.author.orcid0000-0003-3323-4199[8]
unesp.author.orcid0000-0002-9211-4093[9]
unesp.author.orcid0000-0002-8680-2121[10]

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Artigos - Clínica Veterinária - FMVZ
Artigos - Reprodução Animal e Radiologia Veterinária - FMVZ