PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach

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dc.contributor.authorDelabio, Roger
dc.contributor.authorRasmussen, Lucas
dc.contributor.authorMizumoto, Igor
dc.contributor.authorViani, Gustavo-Arruda
dc.contributor.authorChen, Elizabeth
dc.contributor.authorVillares, Joao
dc.contributor.authorCosta, Isabela-Bazzo
dc.contributor.authorTurecki, Gustavo
dc.contributor.authorLinde, Sandra Aparecido [UNESP]
dc.contributor.authorSmith, Marilia Cardoso
dc.contributor.authorPayao, Spencer-Luiz
dc.contributor.institutionFac Med Marilia
dc.contributor.institutionUniv Sagrado Coracao
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionDouglas Hosp
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:56:20Z
dc.date.available2015-03-18T15:56:20Z
dc.date.issued2014-01-01
dc.description.abstractPresenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-beta peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD.en
dc.description.affiliationFac Med Marilia, Sao Paulo, Brazil
dc.description.affiliationUniv Sagrado Coracao, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationDouglas Hosp, Brain Bank, Montreal, PQ, Canada
dc.description.affiliationUniv Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, Lab NeoGene, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade do Sagrado Coracao de Bauru
dc.description.sponsorshipFaculdade de Medicina de Marilia (FAMEMA)
dc.description.sponsorshipIdFAPESP: 09/10777-7
dc.description.sponsorshipIdFAPESP: 09/15857-9
dc.format.extent757-760
dc.identifierhttp://dx.doi.org/10.3233/JAD-140033
dc.identifier.citationJournal Of Alzheimers Disease. Amsterdam: Ios Press, v. 42, n. 3, p. 757-760, 2014.
dc.identifier.doi10.3233/JAD-140033
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/11449/117499
dc.identifier.wosWOS:000342237000004
dc.language.isoeng
dc.publisherIos Press
dc.relation.ispartofJournal Of Alzheimers Disease
dc.relation.ispartofjcr3.476
dc.relation.ispartofsjr1,635
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlzheimer's diseaseen
dc.subjectbrainen
dc.subjectgene expressionen
dc.subjectpresenilin-1en
dc.subjectpresenilin-2en
dc.subjectgamma-secretaseen
dc.titlePSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approachen
dc.typeArtigo
dcterms.licensehttp://www.iospress.nl/service/authors/author-copyright-agreement/
dcterms.rightsHolderIos Press
unesp.author.orcid0000-0002-3573-0164[5]
unesp.author.orcid0000-0002-1441-1033[10]

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