Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate

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dc.contributor.authorAmaral, A. V.C.
dc.contributor.authorSilva, G. A. [UNESP]
dc.contributor.authorCosta, A. P.A.
dc.contributor.authorOliveira, K. S.
dc.contributor.authorJordão, P. [UNESP]
dc.contributor.authorRibeiro, A. P.
dc.contributor.authorRenzo, R. [UNESP]
dc.contributor.authorLaus, J. L. [UNESP]
dc.contributor.institutionUFG-Jataí
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUFG
dc.contributor.institutionUFMT
dc.date.accessioned2018-12-11T17:26:36Z
dc.date.available2018-12-11T17:26:36Z
dc.date.issued2015-01-01
dc.description.abstractSildenafil citrate is a type-5 phosphodiesterase inhibitor (PDE-5), able to inhibit type-6 phosphodiesterase (PDE-6) as well, providing clinical benefits and paraeffects, some of them potentially related to the retina. The effects of the sildenafil on the retrobulbar and retinal circulation were studied in 27 adult male rabbits of the White New Zealand breed. The electric activity of the retina was evaluated before and at the end of the treatments, and immunohistochemistry studies were conducted. An amplitude increase of the b wave was found in the mixed response of cones and rods after 7 days of treatment with sildenafil citrate. However, in the other evaluations and periods, the values did not differ from the basal ones. Through immunohistochemistry, no significant decrease of the expression of PDE-5 and PDE-6 proteins was observed. Based on the results obtained, it is possible to admit that the sildenafil citrate did not change the expression of PDE-5 and PDE-6, neither the electroretinographic activity of the retina of male rabbits of the White New Zealand breed.en
dc.description.affiliationUFG-Jataí
dc.description.affiliationUnesp-Jaboticabal
dc.description.affiliationUFG
dc.description.affiliationUFMT
dc.description.affiliationUnespUnesp-Jaboticabal
dc.format.extent1589-1598
dc.identifierhttp://dx.doi.org/10.1590/1678-4162-7464
dc.identifier.citationArquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 6, p. 1589-1598, 2015.
dc.identifier.doi10.1590/1678-4162-7464
dc.identifier.fileS0102-09352015000601589.pdf
dc.identifier.issn1678-4162
dc.identifier.issn0102-0935
dc.identifier.scieloS0102-09352015000601589
dc.identifier.scopus2-s2.0-84952014149
dc.identifier.urihttp://hdl.handle.net/11449/177679
dc.language.isoeng
dc.relation.ispartofArquivo Brasileiro de Medicina Veterinaria e Zootecnia
dc.relation.ispartofsjr0,248
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectElectroretinography
dc.subjectImmunohistochemistry
dc.subjectRabbit
dc.subjectSildenafil citrate
dc.titleElectroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrateen
dc.typeArtigo
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias