LIPID NANOSTRUCTURED CARRIERS SYSTEMS FOR IVERMECTIN AND METHOPRENE AIMING PARASITE CONTROL
Cola, Diego Faria [UNESP]
Lima, Renata de
Goncalves da Silva, Camila Morais
Fraceto, Leonardo Fernandes [UNESP]
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Soc Brasileira Quimica
The study of characteristics of nanoscale structures and applications now has great interest of researchers from different areas. In this regard, lipid carriers can improve the bioavailability of drugs and the reduction of possible toxicological effects. Thus, the development of nanostructured systems for the agricultural sector, aimed at combating parasites may reduce extensive damage caused to livestock producers and animal health. This study aimed to prepare and characterize lipid carrier systems, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), as well as evaluate the potential of cyto and genotoxicity of these systems in order to improve and produce alternatives to the use targeting these compounds in veterinary applications. Lipid nanoparticles had become spherical with an average size of 250 nm and remained stable over 120 days. The encapsulation efficiency was greater than 99% for both drugs and release tests showed a strong interaction between drugs and nanoparticles. Cyto- and genotoxicity tests show that nanoparticles made possible changes in cellular viability of the tested cells. Thus, the results showed that the nanoparticles had good colloidal characteristics without changes in its characteristics, enabling the development of carrier systems for these drugs, aiming veterinary applications.
lipid nanocarriers, parasites, veterinary, genotoxicity, cytotoxicity
Quimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 39, n. 9, p. 1034-1043, 2016.