beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet
dc.contributor.author | Ferreira, Ederlan de Souza [UNESP] | |
dc.contributor.author | Silva, Maraiza Aparecida [UNESP] | |
dc.contributor.author | Demonte, Aureluce [UNESP] | |
dc.contributor.author | Neves, Valdir Augusto [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:23:44Z | |
dc.date.available | 2014-05-20T13:23:44Z | |
dc.date.issued | 2010-10-01 | |
dc.description.abstract | The hypocholesterolemic effect of isolated soybean proteins and fenofibrate in rats was compared Forty five rats were divided into five groups standard (STD casein) high cholesterol (HC STD plus 1% cholesterol/0 5% cholic acid) HC + beta conglycinin HC + glycinin and HC + fenofibrate The proteins and the drug were administered by gavage for 28 days The proteins decreased total cholesterol (TC) and triacylglycerol (TG) in the plasma of the rats fed HC diet to values very close to those fed on fenofibrate High density lipoprotein cholesterol (HDL C) levels in the plasma were increased by the beta conglycinin glycinin and fenofibrate groups The largest TC reduction in the liver was observed in the fenofibrate group, in contrast the beta conglycinin and glycinin groups exhibited reduced the levels of hepatic TG and TC Based on these data it could be suggested that the oral daily administration of isolated soybean proteins in the range of 2 75% of the protein ingested daily can promote a reduction in TC and TG in the plasma of rats fed hypercholesterolemic diets Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved | en |
dc.description.affiliation | São Paulo State Univ UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação para o Desenvolvimento da UNESP (FUNDUNESP) | |
dc.description.sponsorshipId | FUNDUNESP: 00583/07-DFP | |
dc.description.sponsorshipId | FUNDUNESP: 0041/10-DFP | |
dc.format.extent | 275-283 | |
dc.identifier | http://dx.doi.org/10.1016/j.jff.2010.11.001 | |
dc.identifier.citation | Journal of Functional Foods. Amsterdam: Elsevier B.V., v. 2, n. 4, p. 275-283, 2010. | |
dc.identifier.doi | 10.1016/j.jff.2010.11.001 | |
dc.identifier.file | WOS000285234400007.pdf | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.lattes | 5269969767845353 | |
dc.identifier.lattes | 4031319519910419 | |
dc.identifier.uri | http://hdl.handle.net/11449/7210 | |
dc.identifier.wos | WOS:000285234400007 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Journal of Functional Foods | |
dc.relation.ispartofjcr | 3.470 | |
dc.relation.ispartofsjr | 1,245 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | beta Conglycinin | en |
dc.subject | Glycinin | en |
dc.subject | Fenofibrate | en |
dc.subject | Hypercholesterolemic diet | en |
dc.subject | Dyslipidemia | en |
dc.subject | Rats | en |
dc.title | beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 5269969767845353 | |
unesp.author.lattes | 4031319519910419 | |
unesp.author.orcid | 0000-0003-3558-7019[1] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Alimentos e Nutrição - FCF | pt |
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