beta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet

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dc.contributor.authorFerreira, Ederlan de Souza [UNESP]
dc.contributor.authorSilva, Maraiza Aparecida [UNESP]
dc.contributor.authorDemonte, Aureluce [UNESP]
dc.contributor.authorNeves, Valdir Augusto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:44Z
dc.date.available2014-05-20T13:23:44Z
dc.date.issued2010-10-01
dc.description.abstractThe hypocholesterolemic effect of isolated soybean proteins and fenofibrate in rats was compared Forty five rats were divided into five groups standard (STD casein) high cholesterol (HC STD plus 1% cholesterol/0 5% cholic acid) HC + beta conglycinin HC + glycinin and HC + fenofibrate The proteins and the drug were administered by gavage for 28 days The proteins decreased total cholesterol (TC) and triacylglycerol (TG) in the plasma of the rats fed HC diet to values very close to those fed on fenofibrate High density lipoprotein cholesterol (HDL C) levels in the plasma were increased by the beta conglycinin glycinin and fenofibrate groups The largest TC reduction in the liver was observed in the fenofibrate group, in contrast the beta conglycinin and glycinin groups exhibited reduced the levels of hepatic TG and TC Based on these data it could be suggested that the oral daily administration of isolated soybean proteins in the range of 2 75% of the protein ingested daily can promote a reduction in TC and TG in the plasma of rats fed hypercholesterolemic diets Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserveden
dc.description.affiliationSão Paulo State Univ UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFUNDUNESP: 00583/07-DFP
dc.description.sponsorshipIdFUNDUNESP: 0041/10-DFP
dc.format.extent275-283
dc.identifierhttp://dx.doi.org/10.1016/j.jff.2010.11.001
dc.identifier.citationJournal of Functional Foods. Amsterdam: Elsevier B.V., v. 2, n. 4, p. 275-283, 2010.
dc.identifier.doi10.1016/j.jff.2010.11.001
dc.identifier.fileWOS000285234400007.pdf
dc.identifier.issn1756-4646
dc.identifier.lattes5269969767845353
dc.identifier.lattes4031319519910419
dc.identifier.urihttp://hdl.handle.net/11449/7210
dc.identifier.wosWOS:000285234400007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Functional Foods
dc.relation.ispartofjcr3.470
dc.relation.ispartofsjr1,245
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectbeta Conglycininen
dc.subjectGlycininen
dc.subjectFenofibrateen
dc.subjectHypercholesterolemic dieten
dc.subjectDyslipidemiaen
dc.subjectRatsen
dc.titlebeta-Conglycinin (7S) and glycinin (11S) exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol dieten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5269969767845353
unesp.author.lattes4031319519910419
unesp.author.orcid0000-0003-3558-7019[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAlimentos e Nutrição - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas