Polyphenol rich fruit attenuates genomic instability, modulates inflammation and cell cycle progression of offspring from fatty acid intake maternal

Resumo

The aim of this study was to investigate the effect of juçara (Euterpe edulis Mart.) supplementation on the maternal trans fatty acids intake in the livers of 21-day-old offspring. In order for this to happen, histopathological analysis, cytogenetic status, inflammation (COX-2 and TNF-alpha) and cell cycle progression were investigated in this setting. On the first day of pregnancy, female rats were distributed into four groups, as follows: control diet (C), control diet with 0.5 % juçara supplementation (CJ), diet enriched with hydrogenated vegetable fat, rich in TFAs (T), or T diet supplemented with 0.5 % juçara (TJ) during pregnancy and lactation. Juçara pulp induced liver regeneration in newborns exposed to maternal trans fatty acids. A significant decrease in the number of micronucleated hepatocytes was observed in animals exposed to trans fatty acids and treated with juçara. COX-2 and TNF immunoexpression was reduced in animals treated with juçara pulp. Furthermore, a decrease of Ki-67 immunoexpression was detected after treating trans fatty acids intake with juçara. Taken together, our results demonstrate that juçara pulp is able to prevent tissue degeneration and mutagenicity because it decreases inflammation and cell cycle control induced by maternal trans fatty acids in liver cells of rat offspring.

Descrição

Palavras-chave

Cell cycle progression, Inflammation, Maternal fat diet, Micronucleus offspring, Rat

Como citar

Pathophysiology.