Oral chronic graft-versus-host disease: analysis of dendritic cells subpopulations

Página do item simplificado
dc.contributor.authorBotari, Clara Marino Escpricigo
dc.contributor.authorNunes, Adauto José Ferreira
dc.contributor.authorSouza, Mair Pedro de
dc.contributor.authorRaduan, Érica Sinara Lenharo Orti
dc.contributor.authorSalvio, Ana Gabriela [UNESP]
dc.contributor.institutionHospital Fundação Amaral Carvalho
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-04-01T18:46:51Z
dc.date.available2016-04-01T18:46:51Z
dc.date.issued2014
dc.description.abstractThe graft-versus-host disease is the major cause of morbidity and mortality in patients who have undergone hematopoietic stem cell transplantation. Aiming at contributing to the understanding of the role of myeloid and plasmacytoid dendritic cells, and natural killer cells in chronic graft-versus-host disease, we examined biopsies of jugal mucosa of 26 patients with acute myeloid leukemia who had undergone allogenic hematopoietic stem cell transplantation. Half of these patients developed oral chronic graft-versus-host disease. Microscopic sections were immunohistochemically stained for anti-CD1a, anti-CD123 and anti-CD56. We calculated the number of immunostained cells in the corium per square millimeter and applied the Mann-Whitney test. Results showed a statistically significant increase of myeloid dendritic cells (CD1a+; p=0,02) and natural killer cells (CD56; p=0,04) in patients with oral chronic graft-versus-host disease. CD123 immunostaining showed no statistical difference between groups. It was concluded that myeloid dendritic cells and natural killer cells participate in the development of oral chronic graft-versus-host disease.en
dc.description.affiliationHospital Fundação Amaral Carvalho - Jaú (SP), Brazil
dc.description.affiliationUniversidade Estadual Paulista "Júlio de Mesquita Filho", Programa de Pós-Graduação em Pesquisa e Desenvolvimento: Biotecnologia Médica, Faculdade de Medicina de Botucatu, Botucatu (SP), Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista "Júlio de Mesquita Filho", Programa de Pós-Graduação em Pesquisa e Desenvolvimento: Biotecnologia Médica, Faculdade de Medicina de Botucatu, Botucatu (SP), Brazil
dc.format.extent632-637
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20142464
dc.identifier.citationAnais Brasileiros de Dermatologia, v. 89, n. 4, p. 632-637, 2014.
dc.identifier.doi10.1590/abd1806-4841.20142464
dc.identifier.fileS0365-05962014000400632.pdf
dc.identifier.issn1806-4841
dc.identifier.lattes9878648143577124
dc.identifier.scieloS0365-05962014000400632
dc.identifier.urihttp://hdl.handle.net/11449/137690
dc.language.isoeng
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectCélulas dendríticasen
dc.subjectDoença enxerto contra hospedeiro crônicaen
dc.subjectMucosa bucalen
dc.titleOral chronic graft-versus-host disease: analysis of dendritic cells subpopulationsen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0365-05962014000400632.pdf
Tamanho:
275.54 KB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Artigos