ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women

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dc.contributor.authorMalfará, Bianca Nayra [UNESP]
dc.contributor.authorBenzi, Jhohann Richard de Lima
dc.contributor.authorde Oliveira Filgueira, Gabriela Campos
dc.contributor.authorZanelli, Cleslei Fernando [UNESP]
dc.contributor.authorDuarte, Geraldo
dc.contributor.authorde Carvalho Cavalli, Ricardo
dc.contributor.authorde Moraes, Natália Valadares [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:14:55Z
dc.date.available2019-10-06T16:14:55Z
dc.date.issued2019-04-01
dc.description.abstractNifedipine, a known substrate to breast cancer resistance protein (ABCG2/BCRP), is used for the treatment of hypertension during breastfeeding. This study aimed to evaluate the effect of ABCG2 c.421C>A on nifedipine transfer to breast milk (BM) in hypertensive women. Nineteen hypertensive breastfeeding women treated with 20 mg nifedipine every 12 hours were investigated. Blood and BM samples were collected simultaneously 15–30 days after delivery and at least 15 days after drug treatment. Patients genotyped as ABCG2 c.421CC showed nifedipine plasma and BM concentrations ranging from 8.32–178.1 ng/mL and 4.8–58.5 ng/mL, respectively. ABCG2 c.421C>A showed a trend towards significance (p = 0.0793) on nifedipine in BM, with concentrations approximately 3 times higher in the heterozygous 421 CA (29 ng/mL) in comparison to 421 CC (10.5 ng/mL). Nifedipine BM/plasma ratio was significantly lower in 421CC when compared to 421CA (p = 0.01). In conclusion, ABCG2 c.421C>A polymorphism is associated with higher transfer of nifedipine to BM.en
dc.description.affiliationDepartment of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationDepartment of Gynecology and Obstetrics School of Medicine of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.format.extent1-5
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2019.01.007
dc.identifier.citationReproductive Toxicology, v. 85, p. 1-5.
dc.identifier.doi10.1016/j.reprotox.2019.01.007
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.lattes1525665408900195
dc.identifier.orcid0000-0001-7831-1149
dc.identifier.scopus2-s2.0-85060350217
dc.identifier.urihttp://hdl.handle.net/11449/188653
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBreast cancer resistance protein
dc.subjectBreast milk
dc.subjectHypertension
dc.subjectNifedipine
dc.titleABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding womenen
dc.typeArtigo
unesp.author.lattes1525665408900195[4]
unesp.author.orcid0000-0001-6986-6193[2]
unesp.author.orcid0000-0002-4389-058X[7]
unesp.author.orcid0000-0001-7831-1149[4]
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas