Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing

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dc.contributor.authorDias, Fernanda Gosuen Gonçalves
dc.contributor.authorde Freitas Pereira, Lucas
dc.contributor.authorFurtado, Ricardo Andrade
dc.contributor.authorMagalhães, Geórgia Modé
dc.contributor.authorMiguel, Marina Pacheco
dc.contributor.authorDias, Luis Gustavo Gosuen Gonçalves [UNESP]
dc.contributor.authorJorge, Adriana Torrecilhas
dc.contributor.authordos Santos Honsho, Cristiane
dc.contributor.authorAmbrósio, Sérgio Ricardo
dc.contributor.authorBastos, Jairo Kenupp
dc.contributor.authorCarrijo, Micaela Silva
dc.contributor.authorTavares, Denise Crispim
dc.contributor.institutionUniversidade de Franca
dc.contributor.institutionInstituto Federal do Sul de Minas Gerais
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:46:41Z
dc.date.available2022-04-28T19:46:41Z
dc.date.issued2021-03-01
dc.description.abstractObjective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO). Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days. Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic erythrocytes to total erythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity. Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds.en
dc.description.affiliationDepartment of Veterinary Medicine Universidade de Franca
dc.description.affiliationDepartment of Veterinary Medicine Instituto Federal do Sul de Minas Gerais
dc.description.affiliationDepartment of Veterinary Medicine Universidade Federal de Goiás
dc.description.affiliationDepartment of Veterinary Medicine Universidade Estadual Paulista
dc.description.affiliationDepartment of Sciences Universidade de Franca
dc.description.affiliationDepartment of Pharmacy Universidade de São Paulo
dc.description.affiliationUnespDepartment of Veterinary Medicine Universidade Estadual Paulista
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2011/13630-7
dc.format.extent120-133
dc.identifierhttp://dx.doi.org/10.22038/AJP.2020.16821
dc.identifier.citationAvicenna Journal of Phytomedicine, v. 11, n. 2, p. 120-133, 2021.
dc.identifier.doi10.22038/AJP.2020.16821
dc.identifier.issn2228-7949
dc.identifier.issn2228-7930
dc.identifier.scopus2-s2.0-85118420099
dc.identifier.urihttp://hdl.handle.net/11449/222790
dc.language.isoeng
dc.relation.ispartofAvicenna Journal of Phytomedicine
dc.sourceScopus
dc.subjectCopaifera duckei Dwyer oleoresin
dc.subjectCutaneous wound healing
dc.subjectToxicity
dc.titleTopical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healingen
dc.typeArtigo

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