Blood plasma proteome alteration after local tissue damage induced by Bothrops erythromelas snake venom in mice

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dc.contributor.authorCavalcante, Joeliton S. [UNESP]
dc.contributor.authorBorges da Silva, Weslley Ruan G.
dc.contributor.authorde Oliveira, Laudicéia Alves [UNESP]
dc.contributor.authorBrito, Ingrid Mayara C. [UNESP]
dc.contributor.authorMuller, Kevin S. [UNESP]
dc.contributor.authorJ. Vidal, Ivynna Suellen
dc.contributor.authordos Santos, Lucilene Delazari [UNESP]
dc.contributor.authorJorge, Roberta Jeane Bezerra
dc.contributor.authorAlmeida, Cayo
dc.contributor.authorde Lima Bicho, Carla
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionParaíba State University (UEPB)
dc.contributor.institutionFederal University of Ceará (UFC)
dc.contributor.institutionFederal University of ABC
dc.date.accessioned2023-07-29T13:23:05Z
dc.date.available2023-07-29T13:23:05Z
dc.date.issued2022-10-30
dc.description.abstractSnakes of the genus Bothrops are responsible the most snakebites in the Brazil, causing a diverse and complex pathophysiological condition. Bothrops erythromelas is the main specie of medical relevance found in the Caatinga from the Brazilian Northeast region. The pathophysiological effects involving B. erythromelas snakebite as well as the organism reaction in response to this envenomation are not so explored. Thus, edema was induced in mice paws using 2.5 μg or 5.0 μg of B. erythromelas venom, and the percentage of edema was measured. Plasma was collected 30 minutes after the envenomation-induced in mice and analyzed by mass spectrometry. It was identified a total of 112 common plasma proteins differentially abundant among experimental groups, which are involved with the complement system and coagulation cascades, oxidative stress, neutrophil degranulation, platelets degranulation and inflammatory response. Apolipoprotein A1 (Apoa), serum amyloid protein A-4 (Saa4), adiponectin (Adipoq) showed up-regulated in mice plasma after injection of venom, while fibulin (Fbln1), factor XII (F12) and vitamin K-dependent protein Z (Proz) showed down-regulated. The results indicate a protein pattern of thrombo-inflammation to the B. erythromelas snakebite, evidencing potential biomarkers for monitoring this snakebite, new therapeutic targets and its correlations with the degree of envenomation once showed modulations in the abundance among the different groups according to the amount of venom injected into the mice.en
dc.description.affiliationGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo
dc.description.affiliationDepartment of Biology Center of Biological and Health Sciences Paraíba State University (UEPB), Paraíba
dc.description.affiliationInstitute of Biosciences São Paulo University (UNESP - Univ Estadual Paulista), São Paulo
dc.description.affiliationGraduate Program in Translational Medicine Drug Research and Development Center Federal University of Ceará (UFC), Ceará
dc.description.affiliationBiotechnology Institute (IBTEC) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo
dc.description.affiliationDrug Research and Development Center Federal University of Ceará (UFC), Ceará
dc.description.affiliationDepartment of Physiology and Pharmacology School of Medicine Federal University of Ceará (UFC), Ceará
dc.description.affiliationCenter of Mathematics Computing Sciences and Cognition Federal University of ABC, SP
dc.description.affiliationUnespGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo
dc.description.affiliationUnespInstitute of Biosciences São Paulo University (UNESP - Univ Estadual Paulista), São Paulo
dc.description.affiliationUnespBiotechnology Institute (IBTEC) São Paulo University (UNESP - Univ Estadual Paulista), São Paulo
dc.identifierhttp://dx.doi.org/10.1016/j.jprot.2022.104742
dc.identifier.citationJournal of Proteomics, v. 269.
dc.identifier.doi10.1016/j.jprot.2022.104742
dc.identifier.issn1876-7737
dc.identifier.issn1874-3919
dc.identifier.scopus2-s2.0-85138998190
dc.identifier.urihttp://hdl.handle.net/11449/247686
dc.language.isoeng
dc.relation.ispartofJournal of Proteomics
dc.sourceScopus
dc.subjectEdema
dc.subjectInflammation
dc.subjectMass spectrometry
dc.subjectSnake venom
dc.subjectThromboinflammation
dc.titleBlood plasma proteome alteration after local tissue damage induced by Bothrops erythromelas snake venom in miceen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

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Botucatu - FMB - Faculdade de Medicina